antipyretic effect

Aspirin is an orally active, selective, and irreversible inhibitor of COX-1 and COX-2 with IC₅₀ values of 5 and 210 μg mL, respectively. It induces apoptosis, inhibits NF-κB activation and platelet prostaglandin synthesis, thereby preventing thrombosis. Additionally, it acts as a histone deacetylase inhibitor that upregulates p21, exhibiting anti-inflammatory, antipyretic, analgesic, and anti-platelet aggregation activities. Aspirin is commonly used to induce gastric ulcer models.

Expression system: HEK293 Cells
Length: 1-506, Full Length
Activity: Enzyme Activity

Aspirin calcium is the prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)

Lithium acetylsalicylate is an orally active, irreversible inhibitor of cyclooxygenases COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. It can induce apoptosis, inhibit the activation of NF-κB, and suppress the activity of platelet prostaglandin synthase. It is commonly used to induce gastric ulcer models.