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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T23450 | TCS PrP Inhibitor 13 | 5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One | Others |
TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation. | |||
T25532 | IND81 | IND-81,IND 81 | |
IND81 is an antiprion agent that works by extending the lives of prion-infected animals. | |||
T27605 | IND45193 | IND-45193,IND 45193 | |
IND45193, an antiprion agent, acts by reducing PrP(Sc) levels in dividing and stationary-phase cells. | |||
T11801 | L-Atabrine dihydrochloride | Others | |
l-Atabrine dihydrochloride displays antiprion activity. l-Atabrine dihydrochloride is a less active enantiomer of quinacrine. | |||
T61651 | Quinoprazine | ||
Quinoprazine, a powerful inhibitor of Vaccinia virus DNA synthesis (IC50 = 10 μM), exhibits notable antimalarial activity against Plasmodium berghei. Additionally, it demonstrates significant antiprion potency, effective... | |||
T38146 | Chloroguanabenz (acetate) | ||
Chloroguanabenz is an antiprion agent and a derivative of the α2-adrenergic receptor agonist guanabenz . It inhibits prion formation in yeast and mammalian cell-based assays. Chloroguanabenz reduces the levels of both so... | |||
T73416 | BiCAPPA | ||
BiCAPPA, a pioneering bivalent antiprion ligand, effectively reduces the infectious conformational form of prion protein (PrP Sc) in scrapie-infected cells, achieving this at a concentration (EC 50) of 0.32 μM. | |||
T38186 | 6-Amino-8-trifluoromethylphenanthridine | ||
6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine . It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 μM. 6A-8... | |||
T38187 | 6-Aminophenanthridine | ||
6-Aminophenanthridine is an antiprion agent. It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor a... |