antifungal agent 14

Antifungal agent 14 demonstrates potent broad-spectrum antifungal activity, effectively targeting a variety of fungal strains with exceptional minimum inhibitory concentration values.

Antifungalagent 145 (Compound 14') is a potent antifungal agent. It exhibits minimum inhibitory concentrations (MICs) of 4, 8, and 8 μg/mL against Candida albicans, Candida tropicalis, and Cryptococcus neoformans, respectively. By disrupting fungal cell membranes, Antifungalagent 145 rapidly eradicates fungi and effectively inhibits and degrades biofilms. It offers improved safety for use in antifungal research.

Antifungalagent 140 (compound 5p) is a potent broad-spectrum antifungal agent. It functions by targeting the Ras/cAMP/PKA pathway to inhibit hyphal formation and ergosterol biosynthesis, offering a dual mechanism of action. In a murine model of systemic candidiasis, Antifungalagent 140 enhances survival rates, reduces renal fungal burden, and boosts host immune response. It is valuable for studying drug-resistant fungal infections.

Antifungalagent 144 (Compound 3f) is a highly selective antifungal agent against Aspergillus niger, with a minimum inhibitory concentration (MIC) of 7.5 μg/mL. It simultaneously inhibits chitin deacetylase (chitin deacetylase AngCDA) and 1,3-β-glucan synthase (1,3-β-glucan synthase). The compound functions by disrupting the integrity of the fungal cell wall and does not bind to ergosterol. Additionally, Antifungalagent 144 is useful in studying Aspergillus niger infections.

Antifungalagent 142 (Compound B1) is a broad-spectrum antifungal agent. It exhibits significant fungicidal activity against wheat take-all pathogen [Gaeumannomyces graminis var. tritici], gray mold pathogen [Botrytis cinerea], and apple canker pathogen [Valsa mali], with EC50 values of 0.486, 1.83, and 3.66 mg/L, respectively. This compound increases cell membrane permeability and disrupts membrane integrity, thereby hindering normal hyphal growth. Antifungalagent 142 can be utilized as an agricultural fungicide.

Antifungalagent 141, a phenoxazine derivative, is an antifungal compound. It demonstrates potent antifungal activity against Cryptococcus neoformans and Candida albicans, with MIC values of 2 and 4 µg/mL, respectively. Antifungalagent 141 is applicable in research on cryptococcal meningitis.

Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 [CYP3A].

Fluconazole (UK-49858) belongs to the triazole class of antifungal agents and is a CYP51 inhibitor (IC99 = 0.20–0.39 μg/mL against Candida albicans), possessing broad-spectrum antifungal activity, good oral absorption, and cell permeability. This compound is used for the treatment of various invasive fungal infections.

Oxiconazole is a broad-spectrum imidazole antifungal agent with fungicidal activity against T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur. have fungicidal activity, inhibiting ergosterol biosynthesis and disrupting fungal cell membrane integrity by disrupting cytochrome P450 enzymes (lanosterol 14- α demethylase). It also inhibits DNA synthesis and suppresses intracellular ATP concentration.

CYP51-IN-14 (compound 1n), a derivative of Fluconazole, functions as an effective antifungal agent. This compound inhibits Microsporum gypseum and Candida albicans with a minimum inhibitory concentration (MIC80) of 1 μg/mL.

Antibiofilm agent-14 (compound 11) functions as an antibiofilm agent. It exhibits antifungal activity against C.albicans SC5314, with a minimum inhibitory concentration (MIC) of 50 μM.

Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), which catalyzes the demethylation of

(Z)-Lanoconazole is the Z configuration of Lanoconazole, used for investigating dermatophytosis and onychomycosis. It inhibits sterol 14-alpha demethylase, disrupting fungal membrane ergosterol biosynthesis. Lanoconazole is a potent, orally active imidazole antifungal agent with a broad spectrum of activity against fungi both in vitro and in vivo [1] [2].

Voriconazole-D3 is a deuterated compound of Voriconazole. Voriconazole (T0120) has a CAS number of 137234-62-9. Voriconazole (T0120) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.

Voriconazole (Standard) is a reference standard for research and analysis in studies involving Voriconazole. Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.

Voriconazole-D3 (Standard) is a reference standard of Voriconazole-D3 intended for quantitative analysis, quality control, and related biochemical research applications. Voriconazole-d3 is a deuterated compound of Voriconazole. Voriconazole has a CAS number of 137234-62-9. Voriconazole is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.