antibacterial agent

Cinoxacin (Compound 64716), an older synthetic antimicrobial, was related to the quinolone class of antibiotics. Its activity was similar to oxolinic acid and nalidixic acid.

(2S)-4-biphenyl-4-yl-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide is a LpxC inhibitor with IC50 >95.2 nM.

Antibacterial agent 26 is an antimicrobial compound that is a potent DHFR inhibitor (S. aureus DHFR Ki of 0.020 nM).

Antibacterial agent 131 is a compound with antibacterial properties.

Antibacterial agent 132 showed antimicrobial activity against C. parapsilosis (ATCC 22019) and C. krusei (ATCC 6258) with MIC90 values of <0.06 μg mL and 62.50 μg mL, respectively. Antibacterial agent 132 inhibited aromatase enzyme with IC50 of 0.047 μM.

4-(4,5-dibromo-6-oxo-1,6-dihydropyridazin-1-yl)benzene-1-sulfonamide is a sulfonamide derivative used in the synthesis of building blocks for various supramolecular structures such as metal-organic skeletons and coordination polymers. It has antiproliferative activity against a variety of tumor cell lines.

Anti bacterial agent 236 (Compound 4l), an orally effective inhibitor of DNA gyrase and topoisomerase IV (with IC50 values of 3.2 and 300 nM in Staphylococcus aureus, respectively), exhibits broad-spectrum antibacterial activity. It also demonstrates favorable pharmacokinetic properties in mice.

Compound thy2I, also known as Anti bacterial agent 235, exhibits antibacterial activity with a minimum inhibitory concentration (MIC) ranging from 0.5 μg mL to 8 μg mL. This compound effectively targets and kills both Gram-positive and Gram-negative bacteria via a membrane-targeting mechanism and possesses a low resistance frequency.

Anti bacterial agent 241 functions as a histidine kinase (HK) inhibitor, exhibiting IC50 values of 14 µM for CckA and 238 µM for PhoQ. It demonstrates moderate antibacterial activity against Escherichia coli DC2, Crescentia crescentus, and Bacillus subtilis, with minimum inhibitory concentrations (MIC) ranging from 12 to 74 µg mL.

Antibacterial agent 243 is a potent antimicrobial compound with EC50 values of 0.64 mg L for Valsa mali, 26 mg L for allicin, and 0.33 mg L for tebuconazole. It induces hyphal contraction and collapse, triggers the accumulation of reactive oxygen species within cells, modulates antioxidant enzyme activity, initiates lipid peroxidation, and ultimately causes irreversible oxidative damage to Valsa mali cells.

Antibacterial agent 242, a potent inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), demonstrates an IC50 of 5.46 μM against Toxoplasma gondii. It effectively inhibits the enzymatic activity of TgDXR in vitro as well as the proliferation of T. gondii.

Antibacterial agent 246 (compound A33) demonstrates a minimum inhibitory concentration (MIC) ranging from 0.5 to 4 μg mL against 23 species of Gram-positive bacteria. When used in combination with Polymyxin E, it inhibits the growth of various Gram-negative bacteria, showing a partial inhibitory concentration index of 0.066.

Antibacterial agent 245 (Dc-2) serves as an antimicrobial agent effective against plant pathogenic fungi and bacteria, displaying an EC50 of 1.29 μg mL against Botrytis cinerea.

Antibacterialagent 247 (compound 30b) is a bacterium (bacterial) antagonist that significantly inhibits the formation of biofilms by Pseudomonas aeruginosa (IC50=5.8 μM) and various virulence phenotypes. It also enhances the antibacterial activity of combined treatments with tobramycin and polymyxin B.

Antibacterialagent 255 (compound (±)-1) is a potent antibacterial agent, acting as an effective and selective inhibitor of 4-diphosphocytidyl-2-C-methyl-D-erythritol (IspE). It exhibits IC50 values of 13.0, 8.0, and 20 µM against EclspE, KplspE, and AblspE, respectively.

Antibacterialagent 262 (compound A23) is a potent antibacterial agent that inhibits the activity of Xanthomonas oryzae pv oryzae. It also disrupts the integrity of bacterial cell membranes by preventing the formation of biofilms of Xanthomonas oryzae pv oryzae.

Antibacterialagent 119 (Compound 21 g) is a potential antibacterial agent effective against methicillin-resistant Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of less than 1 μg mL against tested strains. It induces reactive oxygen species (ROS) generation and disrupts bacterial cell membranes, causing their rupture. Antibacterialagent 119 exhibits strong antimicrobial activity, low cytotoxicity, rapid bactericidal action, and favorable in vivo antibacterial efficacy.

Antibacterialagent 263 (compound 5a) is a potent antibacterial agent, exhibiting activity against Streptococcus mutans and Staphylococcus aureus.

Antibacterial agent 18 is a multi-arm AIE molecule with antibacterial activity, inhibiting the growth of both gram-positive and gram-negative bacteria by disrupting glycosylation and transpeptidation processes, affecting bacterial cell wall synthesis, useful for studying bacterial infections.

Antibacterial Agent 41 (example 3) is an antibacterial compound.

Antibacterial agent 39 is a potent compound that exhibits antibacterial properties. It effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, another antibacterial agent.

Antibacterial Agent 42 demonstrates potent antibacterial activity by effectively reducing the Minimum Inhibitory Concentration (MIC) of the broad-spectrum antibacterial agent Ceftazidime.

Antibacterial agent 43, is a potent antibacterial compound. It exhibits promising activity against bacterial infections and offers great potential for research purposes.

Antibacterial agent 44 is a novel antibacterial compound (WO2013030735A1, example 7). It exhibits potent antibacterial activity and is suitable for research purposes related to the study of bacterial infections.