anti-seizure

Decanoic Acid (Caprynic acid) acts as a non-competitive AMPA receptor antagonist.

(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural compound derived from the roots and rhizomes of Notopterygium incisum.

Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene reduces seizure severity in a mouse model of epilepsy by inhibiting HMGB1 translocation, inhibits endothelial proliferation through the HMGB1/2-regulated TLR4-NF-κB pathway, and inhibits autophagy by regulating Beclin 1 activity. Inflachromene can be used to study epilepsy.

3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.

Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic and anti-aging effects, it can extend lifespan, increase heat stress-resistance, delay body paralysis, and increase the chemotaxis response in C. elegans models of Alzheimer's disease. Otophylloside B can suppress the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish.

Talampanel (LY-300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models.

LY456236 free base is a selective, non-competitive, orally active antagonist of the glutamate receptor 1 (mGlu1), effectively inhibiting phosphoinositide hydrolysis with an IC50 of 0.145 μM. Additionally, it inhibits EGFR with an IC50 of 0.918 μM. By suppressing the MAPK pathway, LY456236 free base blocks cell proliferation and counters the anti-apoptotic effects of DHPG. This compound is useful for seizure research.

Tesmilifene fumarate (DPPE fumarate) (DPPE fumarate) is an H1C receptor antagonist.

Thiocolchicoside (Thiocolchicine 2-glucoside analog) (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent. It has powerful convulsant activity and should not be used in seizure-prone individuals.

SOMCL-668, a selective and potent sigma-1 receptor allosteric modulator, demonstrates positive modulation in ameliorating social deficits and cognitive impairment triggered by the selective sigma-1 agonist PRE084. Additionally, SOMCL-668 exhibits anti-seizure properties, making it useful for research in psychotic illnesses [1].