anti-arrhythmic activity

Drobuline hydrochloride, an anti-arrhythmic agent with cardiac depressant activity, is used to manage abnormal heart rhythms.

Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medicinal herb Panax ginseng.

DDO-02005 (free base), a potent Kv1.5 potassium channel inhibitor, demonstrates an IC 50 of 0.72 μM. It exhibits effective anti-atrial fibrillation (AF) properties in the CaCl2-ACh AF rat model and anti-arrhythmic activity against aconitine-induced arrhythmias [1].

Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation activity, the mechanism is related to blockade of Ca2+ influx through L-type Ca2+ channels and inhibition of intracellular Ca2+ release may have no relationship with K+ channels.

CTP-amiodarone, a cellular-penetrating conjugate of myocardial cell-targeting peptide and Amiodarone, exhibits anti-arrhythmic activity by blocking Na+, K+, and Ca2+ channels as well as β-adrenergic receptors.