anthrax

PAMAM Dendrimer G0.0 amine functions as a pore-forming channel antagonist, affecting anthrax toxin protective antigen 63 (PA63, IC50 of 231 nM) and Clostridium botulinum C2 toxin subunit (C2IIa, IC50 of 940 nM). At 10 and 20 µM concentrations, it reduces HeLa cell death induced by C2 toxin. Additionally, PAMAM Dendrimer G0.0 amine acts as a nickel chelator. When combined with a chitosan complex on polysulfone membranes, it selectively captures and stores carbon dioxide (CO2) in gas feed systems. It is utilized in synthesizing PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) and PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5). This compound is applicable in research related to infection, cancer, and drug delivery systems.

Surfen dihydrochloride (Aminoquinuride dihydrochloride) is a potent small molecule antagonist of heparin sulfate with antibacterial and antiviral activity, and inhibits anthrax lethal factor, coagulation factor X, and lethal factor.Surfen inhibits the anticoagulant activity of both normal and low-molecular-weight heparin and inhibits heparin sulfation and heparin cleavage enzyme degradation.Surfen inhibits the blockade of FGF2 binding and signaling mediated by heparin acetylsulfate. Surfen inhibits the blockade of acetylheparin sulfate-mediated FGF2 binding and signaling.Surfen inhibits SEVI and semen-mediated enhancement of HIV type 1 infection.

FSBA inhibits covalently anthrax edema factor.

SSM 3 trifluoroacetate is a potent furin inhibitor (EC50= 54 nM). Blocks furin-dependent cell surface processing of anthrax protective antigen-83in vitro.

Procaine penicillin G (Duphapen) (procaine benzylpenicillin) is an antibiotic useful for the treatment of a number of bacterial infections. Specifically, it is used for syphilis, anthrax, mouth infections, pneumonia, diphtheria, cellulitis, and animal bites.

SSM3 TFA is a potent furin inhibitor, blocking furin-dependent cell surface processing of anthrax protective antigen-83 in vitro..

Hexa-D-arginine is an inhibitor of furin,blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo.

SSM3 tetraTFA hydrate, a potent synthetic inhibitor of furin, exhibits an EC50 of 54 nM and a Ki of 12 nM, effectively inhibiting the furin-dependent cell surface processing of anthrax protective antigen-83 in vitro [1] [2].

Obiltoxaximab, a powerful monoclonal antibody against protective antigen (PA), is crucial for preventing anthrax toxin assembly and subsequent cell intoxication. Its application extends to dose translation studies from animal models to humans in the context of inhalational anthrax research [1] [2].

Raxibacumab (ABthrax) is a humanized antibody targeting the protective antigen of Bacillus anthracis, with anti-infective activity, blocking the interaction of anthrax protective antigen with its receptor. It is used in studies of anthrax disease prevention.

Methyl 2-ethylhexanoate (2-Ethylhexanoic Acid Methyl Ester) is a volatile substance with antifungal activity that can be used to study anthrax.

Sakurasosaponin, a saponin extracted from the roots of Primula sieboldii, exhibits potential anticancer properties. It activates the AMPK pathway to induce autophagy and inhibits the proliferation of NSCLC (non-small cell lung cancer) cells. Additionally, Sakurasosaponin possesses antifungal activities, significantly inhibiting the growth of anthrax bacteria.

IN-2-LF, an inhibitor of lethal factor, also demonstrates inhibitory activity against furin, possessing an IC50 of 2 μM. Moreover, when used alongside D6R [1], IN-2-LF significantly enhances protection from anthrax lethal toxin.