annual

Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases. An annual dose of Zoledronate may also prevent recurring fractures in patients with a previous hip fracture. Zoledronic Acid (ZOL 446) is a single 5 mg infusion for the treatment of Paget's disease of bone. In 2007, the FDA also approved Reclast for the treatment of postmenopausal osteoporosis.

Cloquintocet-mexyl, a herbicide, targets and controls coarse annual grasses within the Poaceae family.

Oxyfluorfen (Boxer), a herbicide of the nitrodiphenyl ether class, is used to control annual and perennial broad-leaved weeds and sedges in a variety of field crops.

Pendimethalin is a herbicide with selective that controls annual grasses and certain annual broadleaf weeds.

Imazapic (Imazamethapyr) has a broad herbicidal spectrum and controls a variety of annual grass weeds.

Methyl 2-(4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)propanoate is a selective herbicide, an inhibitor of fatty acid synthesis, and has a systemic effect. After the stem and leaves are treated, it is quickly absorbed by weeds and transmitted to the whole plant, hydrolyzed into acid, and inhibits the growth of root and stem meristems, resulting in death. For soybean, cotton, peanut, rape, nursery, flax, and other broad-leaved crops to control crabgrass, kangaroo, beef tendon grass, barnyard grass, foxtail, chinensis and other annual grass weeds and bermudagrass, imperatae, etc. ineffective against broadleaf grasses and sedges.

Lenacil (634 Hexilure) is an agent of herbicide.Lenacil can inhibit photosynthesis.

Napropamide, a selective systemic amide herbicide, is used to control a variety of annual grasses and broad-leaved weeds.

Dipropetryn, a triazine herbicide, is used to remove annual broadleaf weeds and gramineous weeds.

Chloramben, a herbicide, is used to control the seedlings of annual grasses and broadleaf weeds.

Metoxuron is a phenylurea herbicide. It is used to control annual gramineous weeds and broadleaf weeds in wheat, barley and carrot fields.

Clofop, an obsolete post-emergence herbicide, was used to control annual grasses in a range of crops.

Clodinafop-propargyl, a prominent member of aryloxyphenoxy-propionate herbicides, is employed for postemergence management of annual grasses in cereals, such as Avena, Lolium, Setaria, Phalaris, and Alopecurus spp.

Hydantocidin is an adenosine succinate synthetase inhibitor and a spiral furanose. It is produced by Streptomyces hygroscopicus and exhibits significant herbicidal activity against annual, biennial, and perennial weeds.

Fenuron is a water-soluble herbicide utilized for controlling annual broadleaf weeds and woody plants. It is commonly applied in fields for crops such as beans, spinach, beets, and various other fruits.

Anilofos, a widely used thionoorganophosphate herbicide, is used for pre-emergence and early post-emergence control annual sedges and grass weeds in transplanted rice crops.

Saflufenacil is a uracil-based herbicide used to control annual broadleaf weeds in soybeans and corn.

MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor. MRTX9768 hydrochloride is a synthetic lethal-based inhibitor binding the PRMT5-MTA complex[1]. MRTX9768 inhibits SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC50 3 nM; prolif. IC50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC50 544 nM; prolif. IC50 861 nM)[1].MRTX9768 selectively targets MTAP CDKN2A-deleted tumors[2][1]. In xenograft studies, oral administration of MRTX9768 demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors, with less SDMA modulation observed in bone marrow[1]. [1]. Christopher R. Smith, et al. Abstract LB003: Fragment based discovery of MRTX9768, a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP CDKN2A-deleted tumors. AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA.[2]. Yingqing Chen, et al. Targeting protein arginine methyltransferase 5 in cancers: Roles, inhibitors and mechanisms. Biomed Pharmacother. 2021 Oct 4;144:112252.

Benzobicyclon is a 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor and herbicide that is spectrally active against annual grasses, sedges, and broadleaf weeds without toxicity to rice.