anabasine

Anabasine ((S)-Anabasine) is an alkaloid extracted from tobacco, acting as a full agonist of nicotinic acetylcholine receptors (nAChRs) with insecticidal activity. It depolarizes TE671 cells that endogenously express human myotypic nAChRs.

neuronal nicotinic ACh receptor partial agonist

(±)Anabasine-D4 is the deuterium-labeled version of  (±)Anabasine (T6060).

(±) Anabasine is a muscle relaxant that can be used for muscle relaxation during surgery.

Anabasine HCl is used as a clinical biomarker for tobacco smoke exposure and as an insecticide. It is also a depolarizing NMJ blocker, aromatase inhibitor, nAChr antagonist, and teratogen found in species of Nicotiana.

(R,S)-N-Nitrosoanabasine (NAB) is a tobacco-specific N-nitrosamine (TSNA) identified in tobacco products and electronic cigarettes. It inhibits the cytochrome P450 (CYP) isoform CYP2A13 metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) into 4-oxo-4-(3-pyridyl) butanal (OPB), 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB), and 4-oxo-4-(3-pyridyl) butanoic acid (OPBA), with respective Ki values of 0.23, 0.87, and 0.5 µM. While NAB is not carcinogenic in hamsters, it is carcinogenic in mice.