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alzheimers

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    22
    TargetMol | Inhibitors_Agonists
  • Natural Products
    1
    TargetMol | Natural_Products
Protriptyline hydrochloride
Protriptyline HCl
T02041225-55-4
Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochloride (Protriptyline HCl) blocks the re-uptake of norepinephrine and serotonin by nerve terminals, thereby increasing available norepinephrine and serotonin. In addition, this agent exhibits anticholinergic activity.
  • $29
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TargetMol | Inhibitor Sale
(R)-Pioglitazone
(R)-U 72107
T88433959687-65-1
(R)-Pioglitazone ((+)-pioglitazone), the R enantiomer of Pioglitazone, serves as a selective and orally active peroxisome proliferator-activated receptor (PPARγ) agonist. It exhibits high-affinity binding to the PPARγ ligand-binding domain and is utilized in research related to Alzheimers disease.
  • $1,670
8-10 weeks
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sTGFBR3 antagonist 1
T88867
sTGFBR3 antagonist 1 (Compound p24) is an antagonist of soluble transforming growth factor β receptor 3 (sTGFBR3) that activates the TGF-β signaling pathway while inhibiting the IκBα NF-κB signaling pathway. It inhibits the release of NO induced by LPS in BV2 cells with an IC50 of 0.52 μM. sTGFBR3 antagonist 1 exhibits anti-inflammatory and neuroprotective activities and can enhance the permeability of the blood-brain barrier (BBB). This compound is applicable in research related to Alzheimers disease.
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SBN-284
T88928
SBN-284 (compound 3x) acts as a dual inhibitor of cholinesterases (Cholinesterases) and NLRP3 inflammasomes, demonstrating blood-brain barrier permeability. It exhibits IC50 values of 0.37, 0.31, and 0.29 μM against EeAChE, hAChE, and eqBChE respectively, and an EC50 value of 1 μM against NLRP3. SBN-284 is utilized in Alzheimers disease research.
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K284-6111
T88963702668-62-0
K284-6111 is an orally effective inhibitor of the Chitinase 3-like 1 protein (CHI3L1). It functions by reducing the expression of inflammatory proteins such as iNOS, COX-2, GFAP, and Iba-1, and inhibits both β-secretase (β-secretase) and NF-κB, leading to a suppression of Aβ production. Furthermore, K284-6111 improves memory impairment in mice induced by Aβ1–42, making it useful for research in Alzheimers disease.
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10-14 weeks
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AChE-IN-68
T88977
AChE-IN-68 (compound 2l) is an effective selective AChE inhibitor with an IC50 of 0.040 μM. It exhibits high blood-brain barrier permeability. This compound is utilized in research on neurodegenerative diseases, particularly Alzheimers disease.
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Ciproxifan hydrochloride
FUB-359 hydrochloride
T890991049741-81-2
Ciproxifan hydrochloride (FUB 359) is an effective, selective, orally active, and competitive antagonist of the histamine H3-receptor, exhibiting an IC50 value of 9.2 nM. This compound demonstrates low apparent affinity for other receptor subtypes. Ciproxifan hydrochloride is utilized in research related to age-related diseases and Alzheimers disease.
  • $1,850
4-6 weeks
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BChE-IN-33
T89113
BChE-IN-33 (compound 4r) is an aromatic amino naphthol derivative and an effective inhibitor of butyrylcholinesterase (BChE) with an IC50 of 14.78 µM. It also inhibits CYP2C19, CYP2C9, and CYP2D6. Exhibiting potent antioxidant activity, BChE-IN-33 has shown IC50 values of 150.48 μM, 2.56 μM, and 4.61 μM in DPPH, ABTS, and Ferric-phenanthroline assays, respectively. This compound demonstrates potential for research in Alzheimers disease.
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OX-201
T891582460722-03-4
OX-201 is a selective agonist for OX2R with an EC50 of 8 nM. Pathological proteins produced by neurons are released into the interstitial fluid (ISF) in a neural activity-dependent manner and subsequently cleared from the brain via lymphatic pathways. The efflux of these proteins to the ISF correlates with the wakeful state of neurons. OX-201 can induce neuronal awakening and enhance the release of tau into the hippocampal ISF. While it does not alter hippocampal tau levels, OX-201 has potential applications in Alzheimers disease (AD) related to sleep wake cycle disturbances.
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10-14 weeks
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AChE-IN-67
T89233
AChE-IN-67 (compound 8n) is an effective AChE inhibitor with an IC50 of 0.033 μM, exhibiting activity comparable to Donepezil. It possesses high blood-brain barrier (BBB) permeability and is utilized in Alzheimers disease research.
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Tl45b
T89239
Tl45b is an inhibitor of AChE with an IC50 value of 0.71 μM. It is utilized in the study of Alzheimers disease.
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AChE-IN-71
T892781708114-58-2
AChE-IN-71 (compound 12A) acts as an inhibitor of acetylcholinesterase (AChE). It is utilized in the study of Alzheimers disease.
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10-14 weeks
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Phenserine tartrate
(-)-Phenserine (+)-tartrate,(-)-Eseroline phenylcarbamate tartrate
T89337156910-61-1
Phenserine tartrate ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and functions as an efficient, non-competitive, long-acting, and selective inhibitor of acetylcholinesterase (AChE). This compound reduces the formation of amyloid precursor protein (APP) and β-amyloid peptides (Aβ), potentially improving cognitive abilities and alleviating the progression of Alzheimers disease.
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10-14 weeks
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BuChE-IN-13
T89360
BuChE-IN-13 (compound 3) is a BuChE inhibitor that exhibits anti-Alzheimers activity. It is utilized in the research of neurodegenerative diseases.
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SSZ
T893751262287-23-9
SSZ is a multitarget inhibitor that addresses various pathological mechanisms in Alzheimers disease (AD). It targets acetylcholinesterase (acetylcholinesterase), butyrylcholinesterase (butyrylcholinesterase), β-site amyloid precursor protein-cleaving enzyme 1 (BACE1), and γ-secretase (γ-secretase). In murine models, SSZ has been shown to improve Alzheimers disease and exhibit neuroprotective effects.
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10-14 weeks
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PF-05212377
SAM-760
T893921226793-34-5
PF-05212377 (SAM-760) is an inhibitor of the serotonin receptor 5-HT6. It acts as a substrate for the human transport proteins P-gp non-BCRP. The compound has demonstrated blood-brain barrier permeability in non-human primates. PF-05212377 is utilized in research related to Alzheimers disease.
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10-14 weeks
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NT376
T894392820208-97-5
NT376 is a potent and selective inhibitor of class IIa Histone deacetylases (HDAC), exhibiting an IC50 value of 32 nM and demonstrating efficacy similar to NT160 (IC50 = 46 nM) in HT-29 cells. This compound is a promising candidate for research into various cancers and central nervous system (CNS) disorders, including Alzheimers and Huntingtons diseases.
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10-14 weeks
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SHLP-1
T89474
SHLP-1 is a mitochondria-derived peptide encoded by the MT-RNR2 gene, a biologically active microprotein derived from 16S ribosomal RNA (MT-RNR2). This compound is utilized in research related to diabetes, Alzheimers disease, cardiovascular diseases, and prostate cancer.
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AChE-IN-72
T89586
AChE-IN-72 (Compound 13a) serves as an inhibitor of acetylcholinesterase (AChE) with an IC50 value of 0.59 μM and also inhibits butyrylcholinesterase (BChE) with an IC50 of 5.02 μM. Moreover, this compound exhibits radical scavenging activity, demonstrated by an IC50 of 5.88 μM, and exhibits iron-chelating properties that inhibit the aggregation of Aβ1-42 and the activation of the NLRP3 inflammasome. AChE-IN-72 has shown to ameliorate memory impairments in a Betaine-induced Alzheimers disease (AD) mouse model and possesses blood-brain barrier (BBB) permeability.
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21-Angeloyl-protoaescigenin
(Z)-Protoescigenin 21-tiglate
TN811635931-54-5
21-Angeloyl-protoaescigenin (compound 11) is a bryophyte analogous triterpene (BAT) that can be isolated from the acidic hydrolysis products (AHP) of crude bryophyte seed extracts. BATs are known for their potent antitumor, anti-inflammatory, and anti-Alzheimers activities. However, Protoescigenin 21-tiglate exhibits antitumor activity, showing inhibition efficacy (IC50) of 38.2 μM and 33 μM against MCF-7 and HeLa cells, respectively.
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[D-Ser14]-Humanin
TP2803570382-85-3
[D-Ser14]-Humanin is a biologically active peptide in which the Ser14 residue of Humanin is replaced with its D-form. This variant exhibits effective inhibitory activity against the fibrillation of amyloid-β. Compared to its L-form counterpart, [D-Ser14]-Humanin offers enhanced cellular protective activity against age-related cell death induced by amyloid precursor fibrils and oxidative stress. This compound is utilized in research on Alzheimers disease.
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SHLP-5
TP28221191923-95-1
SHLP-5, a mitochondrial-derived peptide, is encoded by the MT-RNR2 gene which produces a bioactive microprotein. This compound is utilized in researching diabetes, Alzheimers disease, cardiovascular diseases, and prostate cancer.
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