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By Target- ALK
- PSMA(1)
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By Target By ResearchField- Cancer(2)
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Results for "
alkbh3
" in TargetMol Product Catalog.- Inhibitors & Agonists2
W23-1006
T2050343035498-92-8
W23-1006 is a novel, selective, and cell-active covalent inhibitor of ALKBH5 (an m6A RNA demethylase). It functions by binding to the C200 residue of ALKBH5 with an IC50 value of 3.848 μM. W23-1006 demonstrates superior selectivity, being approximately 30-fold and 8-fold more potent against ALKBH5 than against FTO and ALKBH3, respectively. By inhibiting ALKBH5 and increasing global m6A abundance, W23-1006 effectively suppresses proliferation, migration, and colonization in triple-negative breast cancer (TNBC) cells.
- $52
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