acute kidney injury (aki) model

Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.

H111-H7 is an inhibitor of the E3 ubiquitin ligase 27 containing the WW domain (WWP2), with a KD value of 717 nM. In a unilateral ischemia-reperfusion (UIR) mouse model, H111-H7 inhibits the expression of WWP2, restores the level of succinate dehydrogenase complex subunit C (SDHC), and slows the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). H111-H7 is applicable for studying the transition from AKI to CKD.

H36-E4 is an inhibitor of the E3 ubiquitin ligase 27 containing WW domains (WWP2), with a KD value of 6.25 μM. In a unilateral renal ischemia-reperfusion (UIR) mouse model, H36-E4 suppresses WWP2 expression, restores levels of succinate dehydrogenase complex subunit C (SDHC), and slows the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). This compound is useful for research on the progression of AKI to CKD.

GSK-3β Inhibitor 17 (compound 5 n) reduces the expression of p-p65 and KIM-1 proteins in a dose-dependent manner (16, 32, 64 µM) induced by cisplatin. Additionally, at a concentration of 32 µM, it decreases the levels of TNF-α, IL-1β, IL-6, and MCP-1 mRNA in an acute kidney injury (AKI) model of HK-2 cells triggered by cisplatin.