aak-1-in-1

AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research[1]. Adaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases. AAKl mRNA exists in two splice forms termed short and long. The long form predominates and is highly expressed in brain and heart. AAKl is enriched in synaptosomal preparations and is co-localized with endocytic structures in cultured cells. AAKl modulates clatherin coated endocytosis, a process that is important in synaptic vesicle recycling and receptor-mediated endocytosis[1]. [1]. Guanglin Luo, et al. Biaryl kinase inhibitors. WO2015153720A1.

AAK1-IN-10 (Compound 1-2) is an AAK1 inhibitor with significant enzymatic inhibition of AAK1 (IC50: 9.62 nM). Its primary mechanism involves inhibiting adaptor-associated kinase 1 (AAK1) activity. AAK1-IN-10 exhibits minimal cardiotoxicity (IC50 = 13.7 μM) and can be utilized in research for diabetic neuralgia and postherpetic neuralgia.

AAK1-IN-11 is an inhibitor of AAK1 (adaptor associated kinase 1) with an IC50 of 2 nM, and it exhibits antiviral activity.