a-d-glucosidase

α-Glucosidase (α-D-Glucosidase) is a carbohydrate hydrolyzing enzyme that catalyzes the release of α-glucose from the non-reducing end of the substrate, playing a vital role in glucose absorption by the small intestine. Inhibiting α-Glucosidase effectively manages non-insulin-dependent diabetes mellitus (NIDDM).

Naringinase is a hydrolytic enzymatic complex that exhibits α-L-rhamnosidase and β-D-glucosidase activities. It is widely found in nature and is primarily utilized for the biotransformation of steroids, antibiotics, and glycosides.

Glycosidase-IN-1 is a glycosidase inhibitor synthesized from D-mannose with hypoglycemic activity. It can be used to synthesize some immunosuppressive agents and β-glucosidase inhibitors.

Afegostat D-Tartrate is a pharmacological chaperone that binds specifically and reversibly with high affinity to acid-β-glucosidase (GCase) in the endoplasmic reticulum.

α-Glucosidase-IN-45 is an inhibitor of α-glucosidase. It is a novel indole-fused pyrano[2,3-D]pyrimidine compound.

4-Nitrophenyl β-D-cellobioside is a disaccharide and an enzyme substrate. It has been used to characterize the function of endoglucanase 1 from T. harzianum, β-glucosidase from T. xylanolyticum, and glycoside hydrolase family 3 (GH3) aryl β-glucosidases from A. oryzae.

Daucosterol (Sitogluside) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol(β-Sitosterol β-D-glucoside) has efficient and inexpensive neuroprotectant effect, to contribute to IGF1-like activity, could be potentially developed as a medicine for ischemic stroke treatment.

Prunetin 5-O-β-D-glucopyranoside, an isoflavone obtained from Potentilla astracanica extracts, is a potent uncompetitive inhibitor of α-glucosidase (IC 50 = 56.05 μg/mL). It serves as a valuable tool for type-2 diabetes research.

Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1.4 microM and has inhibitory effects of sorbitol accumulation, suggests that it is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications.

pNPG-1(4-Nitrophenyl β-D-glucuronide) is a glucuronide monosaccharide derivative that is a chromogenic substrate for β-glucosidase.

2-Nitrophenyl a-D-glucopyranoside is a substrate of β-glucosidase [1].

4-Methylumbelliferyl-α-D-Glucopyranoside (4MU-αGlc) is a pH-dependent α-glucosidase fluorometric substrate, a biomarker for Fabry and Pompe diseases, quantifying α-glucosidase activity in infant blood spots.

alpha-Spinasterol glucoside (α-Spinasterol-3-O-β-D-glucoside) is a natural sterol glucoside exhibiting weak inhibitory activity against alpha-glucosidase (IC₅₀ = 75.9 µM).

Isorhamnetin-3-O-glucoside (Standard) is a reference standard for research and analysis in studies involving Isorhamnetin-3-O-glucoside. Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1.4 microM and has inhibitory effects of sorbitol accumulation, suggests that it is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications.

Panosialin D inhibits α,β-glucosidase and mannosidase enzymes, but does not inhibit the influenza virus. It exhibits a mild antibacterial effect.

(6-O-p-Coumaroyl)-β-D-glucopyranosyl-2-O-(4-hydroxybenzoyl)-4-O-β-D-glucopyranosyl-6-hydroxyphenylacetate is a selective inhibitor of α-glucosidase (IC50 = 10.53 μg/mL), exhibiting both anti-fibrotic and anti-diabetic properties. It inhibits the growth of mouse hepatic stellate cells (t-HSC/Cl-6) with an IC50 of 109.2 μg/mL. This compound can be isolated from ester derivatives of Impatiens balsamina L. flowers and is applicable in research focused on liver fibrosis and type 2 diabetes.

Apigenin 5-O-beta-D-glucopyranoside has inhibitory activity against the enzyme yeast a-glucosidase, withthe IC50 value of 287.12 muM.

β-Glucosidase, Clostridium thermocellum (EC 3.2.1.21), is a glucosidase enzyme that targets β1→4 glycosidic bonds connecting two glucose or glucose-substituted molecules, such as cellobiose. This exocellulase enzyme is specific to various β-D-glycoside substrates. It catalyzes the hydrolysis of terminal non-reducing β-D-glucoside residues, releasing glucose.

β-Glucosidase, Bacteroides fragilis (EC 3.2.1.21), is a glucosidase enzyme that targets the β1→4 glycosidic bonds between two glucose molecules or glucose-substituted molecules, such as cellobiose. It serves as an exocellulase and exhibits specificity for various β-D-glucoside substrates. β-Glucosidase catalyzes the hydrolysis of the non-reducing terminal residues of β-D-glucosides, releasing glucose.

β-Glucanase 1(thermostable) is a glucosidase located at the brush border of the small intestine, targeting β1→4 glycosidic bonds between glucose or glucose-substituted molecules (such as the disaccharide cellobiose). This enzyme is an exocellulase specific to various β-D-glycosidic substrates. It catalyzes the hydrolysis of non-reducing terminal residues of β-D-glucosides, releasing glucose.

β-Glucosidase, Rhizobium etli (EC 3.2.1.21), is a glucosidase enzyme that targets β1→4 glycosidic bonds connecting two glucose or glucose-substituted molecules (such as disaccharide cellobiose). As an exocellulase, β-Glucosidase exhibits specificity for various β-D-glycoside substrates, catalyzing the hydrolysis of terminal non-reducing β-D-glucoside residues to release glucose.

β-Glucanase 2 (thermostable) is a glucosidase located at the brush border of the small intestine, acting on β1→4 glycosidic bonds connecting two glucose or substituted glucose molecules (such as disaccharide cellodextrin). It is an exocellulase with specificity for various β-D-glycoside substrates, catalyzing the hydrolysis of non-reducing terminal β-D-glucosidic residues to release glucose.

β-Glucosidase (thermostable) is a glucose-metabolizing enzyme found in the brush border of the small intestine, targeting the β1→4 glycosidic bonds joining two glucose or glucose-substituted molecules, such as in disaccharides like cellobiose. This enzyme functions as an exocellulase with specificity for various β-D-glycoside substrates. It facilitates the hydrolysis of terminal non-reducing residues in β-D-glucosides, resulting in the release of glucose.

4-Nitrophenyl β-D-mannopyranoside serves as a valuable substrate for β-D-mannopyranosidase. Additionally, it acts as a substrate for GH1-glucosidase (EaBgl1A) and α-L-rhamnosidase.