a-1874

A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.

MEDI4212 is a humanized IgG1λ monoclonal antibody inhibitor targeting IgE. It effectively inhibits human IgE-mediated functional responses, such as calcium signaling, β-hexosaminidase release, and phagocytosis, through its receptor FcεRI. MEDI4212 prevents IgE from binding to CD23 with an IC50 of 8 nM and can be utilized in severe asthma research.

Compound Fr14451, with CAS No. 1874-85-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr14451 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.