T8222

Selpercatinib (LOXO-292) is a tyrosine kinase inhibitor with antineoplastic properties, displaying IC50 values of 14.0 nM for RET (WT), 24.1 nM for RET (V804M), and 530.7 nM for RET (G810R).

Head activator neuropeptide, a mitogen for neuronal or neuroendocrine mammalian cell lines, induces mitosis by signaling through GPR37 binding [1].

H-D-MeAla-EtVal-Val-MeLeu-Ala-D-Ala-MeLeu-MeLeu-MeVal-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe is a derivative of cyclosporin A, lacking immunosuppressive properties, with potential applications in congenital muscular dystrophy research [1].

HDAC6-IN-25 (compound 8) is a potent and selective HDAC6 inhibitor with an IC50 value of 0.6 nM [1].

HDAC6-IN-24 (compound N1) is an inhibitor of histone deacetylase 6 (HDAC6) [1].

HDAC6-IN-21 (compound 13) is an irreversible inhibitor of histone deacetylase 6 (HDAC6) [1].

HDAC1/CDK7-IN-1 (compound 8e) is a dual inhibitor of CDK7 and HDAC1, with IC50 values of 893 nM and 248 nM, respectively. It suppresses the proliferation of cancer cell lines such as MDA-MB-231, MCF-7, A549, and HCT-116, induces cell cycle arrest and apoptosis in HCT-116 cells, and impedes their migration [1].

HD5, a naturally occurring lectin-like peptide from human defensins-5, is secreted by Paneth cells in the crypts of Lieberkühn and has the capability to bind with glycosylated proteins and lipid components.

HA-2a inhibits the JAK2/STAT3 pathway by downregulating circDcbld2 expression in RAW264.7 cells [1].