T7813

α-MSH (MSH, amide) is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.

Emtricitabine triphosphate tetrasodium salt is the tetrasodium form of the phosphorylated anabolite (-)-Emtricitabine triphosphate, an active nucleoside reverse transcriptase inhibitor effective against HIV and HBV [1].

Sucunamostat (SCO-792) hydrochloride is an orally active, reversible inhibitor of enteropeptidase, displaying inhibition constants (IC50) of 4.6 nM for rat enteropeptidase and 5.4 nM for human enteropeptidase. In vitro, it dissociates slowly from enteropeptidase, while in vivo, it hinders protein digestion [1].

AA74-1 is a potent, selective APEH inhibitor that significantly enhances T-cell proliferation by inhibiting APEH activity [1].

Nicotelline (Nicotellin) is a biomarker and environmental tracer for tobacco smoke particles, a relatively non-volatile alkaloid found in tobacco smoke, and a weak inhibitor of cytochrome P-450 2A6 (CYP2A6). It is used to distinguish tobacco products.

Perindopril acyl-β-D-glucuronide is a metabolite of the ACE inhibitor perindopril [1].

Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, including pancreatic cancer, characterized by abnormal and pronounced CDK1 expression [1].

SIC5-6 is a potent inhibitor of Separase, a substantial cysteine protease implicated in critical cellular processes such as chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, as well as spindle stabilization and elongation. Given its overexpression in many solid cancers, Separase presents an attractive target for chemotherapy [1].

Dimethylamiloride hydrochloride selectively inhibits Na⁺/H⁺ exchangers located in cellular membranes, leading to intracellular H⁺ retention and a reduction in intracellular pH, Dimethylamiloride hydrochloride additionally blocks TRPA1 ion channels with an IC50 of 80 µM, making it a valuable pharmacological tool for studying ion transport, pH homeostasis, sensory signaling, and inflammatory pain mechanisms.

α-MSH acetate is an endogenous neuromodulatory peptide derived from POMC and an agonist of MC4R (melanocortin receptor 4). It inhibits food intake, fever, and inflammation, exhibiting multiple biological activities.