T7811

Pilsicainide HCl (SUN 1165) is a pure sodium channel blocker

DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist with the molecular structure p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2, used for in vivo tumor tracing via isotopic labeling, such as 177Lu-DOTA-LM3 TFA and 68Ga-DOTA-LM3 TFA. The 68Ga-labeled compound shows favorable biodistribution, high tumor uptake, good tumor retention, and minimal safety concerns, while the 177Lu-labeled variant targets DOTATOC-negative liver metastases, including pancreatic NET and extensive tumor thrombosis [1] [2].

NCS-382 (sodium) is a potent GABA receptor antagonist with anti-sedative and anti-hypnotic properties, used in neurological disease research [1].

Voxvoganan (LTX-109) trihydrochloride is a topical antimicrobial with high efficacy against S. aureus, exhibiting a MIC range of 2 to 4 μg/mL. It is used in research for treating bacterial skin infections, fungal infections, and nasal decolonization of MRSA [1] [2].

Tylvalosin (Acetylisovaleryltylosin) is a broad-spectrum macrolide antibiotic with antibacterial and antiviral properties, effective against PRRSV infection. It induces apoptosis and possesses anti-inflammatory activity. Furthermore, Tylvalosin mitigates oxidative stress and acute lung injury through the suppression of NF-κB activation [1] [2].

Phenethicillin sodium (α-Phenoxyethylpenicillin) is a penicillin-class antibiotic with antimicrobial activity [1].

Antifungal agent 48 (Example 308), active against Cryptococcus neoformans, exhibits a minimum inhibitory concentration (MIC) value of 11 μM [1].

Antifungal agent 49 (Example 112) demonstrates activity against Cryptococcus neoformans with a minimum inhibitory concentration (MIC) of 49 μM [1].

FN-439 TFA is a selective inhibitor of collagenase-1 with an IC50 of 1 μM, used in cancer and inflammation research [1] [2].

Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase. This tripeptide derivative emulates a segment of the human cysteine proteinase-binding center and demonstrates selective antiviral activity, inhibiting herpes simplex virus (HSV) yet exhibiting negligible impact on poliovirus replication. Notably, Z-LVG-CHN2 effectively impedes SARS-CoV-2 replication with an EC50 value of 190 nM by targeting the SARS-CoV-2 3CL protease [3].