T7412

Tandospirone citrate (SM-3997 citrate) is a potent and selective 5-HT1A receptor partial agonist (Ki : 27 nM)

DMT-dA(PAc) Phosphoramidite is a diPhosphoramidite suitable for DNA or RNA synthesis applications.

PROTAC BRD4 Degrader-11 (compound 9a), a PROTAC linked through ligands to von Hippel-Lindau and BRD4, effectively targets and degrades the BRD4 protein in PC3 prostate cancer cells when conjugated with STEAP1 and CLL1 antibodies, exhibiting potent activity with DC50 values of 0.23 nM and 0.38 nM for the respective conjugations [1].

PROTAC BRD4 Degrader-12 (compound 9c) is a PROTAC that links von Hippel-Lindau and BRD4 ligands. When conjugated with STEAP1 and CLL1 antibodies, this compound effectively degrades BRD4 protein in PC3 prostate cancer cells, demonstrating potent activity with DC50 values of 0.39 nM and 0.24 nM, respectively [1].

PROTAC BRD4 Degrader-14, a PROTAC (Proteolysis Targeting Chimera) linked by ligands to von Hippel-Lindau and BRD4, exhibits IC50 values of 1.8 nM and 1.7 nM for BRD4 BD1 and BD2, respectively. This compound effectively degrades the BRD4 protein in PC3 prostate cancer cells [1].

N-Desethyl Sunitinib hydrochloride (SU-12662 hydrochloride) is an active metabolite of Sunitinib with potential anti-cancer activity for the study of cancer.

NCGC00188636 (also known as DBS) is a novel covalent pyruvate kinase (PYK) inhibitor. It exerts its effect by binding to the active site of pyruvate kinase and blocking nucleotide binding. The compound demonstrates potent inhibitory activity against Leishmania mexicana pyruvate kinase (LmPYK) and is used to investigate energy metabolism across various organisms and cell types.

L-Homocysteic acid (L-HCA), an endogenous excitatory amino acid, serves as a NMDA receptor agonist (EC 50: 14 μM) and exhibits neurotoxic properties. It is utilized in the study of neurological disorders [1] [2] [3].