T7344

SDMA (Symmetric dimethylarginine) is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD).

ccc_R08 is an orally available HBV cccDNA inhibitor that reduces extracellular levels of HBV DNA, HBsAg, and HBeAg in a dose-dependent manner. ccc_R08 is investigational for use in the treatment of HBV infections. ccc_R08 has been shown to be effective in the treatment of hepatitis C virus (HCV).

NP10679 is an orally available, selective, brain-penetrating, potent, and pH-sensitive N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit.NP10679 inhibits histamine H1, hERG channels, and CYP enzymes, and may be useful in the study of epilepsy and ischemic stroke.

TBI-166, an orally active riminophenazine analogue, serves as an anti-tuberculosis agent and exhibits fewer adverse reactions compared to its lead compound, Clofazimine [1] [2] [3].

KM04416 is a GPD2 inhibitor that inhibits LUAD progression by modulating immune cell infiltration.

STL1267 is a REV-ERB agonist that can cross the blood-brain barrier and inhibits BMAL1 gene expression. It can be used to study chronic diseases and inflammatory pain.

BRD7586 is a cell-permeable small molecule inhibitor of SpCas9 that enhances SpCas9 specificity.

TIM-063 is a selective, cell-permeable inhibitor of CaMKK that competes with ATP, directly targeting the catalytic domain of CaMKK. It exhibits K(i) values of 0.35 μM for CaMKKα and 0.2 μM for CaMKKβ, with respective IC(50) values of 0.63 μM and 0.96 μM.

BI‑3231 is a selective and potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 HSD17B13, inhibiting hHSD17B13 and mHSD17B13.BI-3231 can be used for the study of alcohol-associated liver injury, fibrosis and cirrhosis.

CZS-241 is an orally active, selective Polo-like Kinase (PLK) 4 inhibitor with an IC 50 of 2.6 nM that also inhibits TRKA at an IC 50 of 2.74 μM. It induces apoptosis and causes cell cycle arrest at the S/G2 phase, demonstrating potent antiproliferative effectiveness against leukemia cell lines while maintaining safety towards normal cell lines.

N,N'-Dimethylarginine-D6 is a 2H-labeled N,N'-Dimethylarginine (TMSM-3660), a 202-Da methylated analog of the amino acid arginine, formed during post-translational methylation by methyltransferases.