T6223

U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity. U0126-EtOH inhibited autophagy and mitophagy.

AMPK activator 4 is a potent and selective AMPK activator that does not inhibit mitochondrial complex I. It selectively activates AMPK in muscle tissue, dose-dependently improves glucose tolerance in normal mice, significantly reduces fasting glucose levels, and improves insulin resistance in db/db diabetic mice. [AMPK activator 4 has hypoglycemic effects.]

Cdc7-IN-10 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in studies of proliferative diseases.

Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.

PHGDH-IN-2 is a potent NAD+-competitive PHGDH inhibitor (IC50: 5.2 μM) that exhibits inhibitory effects on the growth of PHGDH-dependent cancer cells and inhibits the serine synthesis pathway in [MDA-MB-468] cells.

ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).

JAK3/BTK-IN-3 is a potent inhibitor of JAK3/BTK and targets two important pathways in autoimmune diseases. The simultaneous inhibition of the BTK/JAK3 signaling pathway exhibits a synergistic effect, highlighting JAK3/BTK-IN-3's potential for investigating JAK3 kinases and/or BTK-related diseases.

CDK-IN-9 (compound 24) is a potent inhibitor of CDK and acts on CDK2/E (IC50: 4 nM). It functions as a molecular gel that induces interaction between CDK12 and DDB1, and can dephosphorylate retinoblastoma protein and RNA polymerase II, thereby inducing apoptosis.

Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 [17β-HSD1], useful in studying endometriosis and other estrogen-dependent diseases.

Steroid sulfatase-IN-4 (Compound 16) is an irreversible inhibitor of human steroid sulfatase (STS) with an IC50 of 25 nM, and can be used to study endometriosis.

HSR1304 (Compound 5d) is a potent inhibitor of NFκB, a multifunctional transcription factor implicated in various human diseases, including cancer and chronic inflammation. It shows significant potential for cancer research.