T6115

Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.

Beclobrate (Sgd 24774) is a novel orally available fibric acid derivative that has shown significant lipid and cholesterol-lowering activity in rodents and may be used in the study of primary hyperlipoproteinemia.

Oleyl Mesylate, a derivative of oleyl alcohol, can be incorporated into various formulations.

Antibacterial agent 26 is an antimicrobial compound that is a potent DHFR inhibitor (S. aureus DHFR Ki of 0.020 nM).

FTO-IN-8, also known as FTO-43, is an inhibitor of N6-methyladenosine demethylase FTO (fat mass- and obesity-associated protein). It exhibits an IC50 value of 5.5 μM and displays anti-cancer cell proliferative activity [1].

Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities. Mepazine hydrochloride inhibits RANK-induced osteoclastogenesis, suppresses MALT1 activity and tumor growth in pancreatic cancer.

Colistin adjuvant-2 is a compound that acts as a potentiation agent for colistin, effectively enhancing its activity against Gram-negative bacteria [1].

D-Cl-amidine hydrochloride, a potent and highly selective inhibitor of PAD1, exhibits excellent tolerance and does not induce significant toxicity [1].

Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM, demonstrating efficacy in reducing parasite burden in vivo and holding promising potential for infection research. [1]