T4117

Zuclopenthixol (cis-Clopenthixol) is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

OB 24 hydrochloride is a selective, orally active HO-1 inhibitor (IC50=1.9 μM) exhibiting antitumor and anti-metastatic properties, suitable for studying prostate cancer, melanoma, ovarian cancer, and lung cancer metastasis.

PARPYnD is a potent photoaffinity probe for poly(ADP-ribose) polymerase (PARP) (IC50 values for PARP2, PARP1 and PARP6 are 6, 38 and 230 nM, respectively). PARPYnD labels PARP1 and PARP2 in the cell when an N3 functionalized fluorescent probe is attached and can inhibit isolated PARP6.

Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide.In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (EC50values range from 3 μM to >100 μM). Galidesivir protects against Ebola and Marburg viral infection in animal models.

FAM-DEALA-Hyp-YIPD is a fluorescent HIF-1α peptide (Kd= 180-560 nM) used to assess VHL binding in Fluorescence Polarization (FP) displacement assays and evaluate the effect of VHL binding on degradation activity. It has an excitation maximum of 485 nm and an emission maximum of 535 nm. A longer peptide version, FAM-DEALAHypYIPMDDDFQLRSF, is also available.

SSM 3 trifluoroacetate is a potent furin inhibitor (EC50= 54 nM). Blocks furin-dependent cell surface processing of anthrax protective antigen-83in vitro.

Zuclopenthixol decanoate is an anti-schizophrenia drug.

Zuclopenthixol dihydrochloride is an D1 and D2 dopamine receptors antagonist.