T21746

Terameprocol (EM-1421) is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol showed the strongest anti-HIV activity.

Lixadesiran is an siRNA component of STP705, specifically targeting COX-2. STP705 comprises two siRNAs, Pixofisiran and Lixadesiran, which target TGF-β1 and COX-2 mRNA, respectively.

Vortosiran is an siRNA with anticoagulant properties, capable of inhibiting the synthesis of blood coagulation factor XI.

Edutirsen sodium is an antisense oligonucleotide that inhibits the synthesis of 1-acylglycerol-3-phosphate O-acyltransferase (PNPLA3).

Umedaptanib pegol is a nucleic acid aptamer targeting anti-fibroblast growth factor-2 (FGF2), and it is utilized in the research of neovascular age-related macular degeneration (nAMD).

Lexaptepid Pegol sodium is a PEGylated L-oligonucleotide capable of binding to hepcidin and inhibiting its activity.

Gatuzosiran sodium is an siRNA and a synthetic inhibitor of 17-β-hydroxysteroid dehydrogenase 13 (HSD17B13), used in the study of fatty liver diseases.

Solbinsiran sodium is an siRNA compound that targets the ANGPTL3 protein in the liver and is used for research in dyslipidemia.

Movronersen is an antisense oligonucleotide targeting α-synuclein.

Elsunersen is an antisense oligonucleotide designed to selectively reduce the expression of the SCN2A gene. It is utilized in the study of SCN2A developmental and epileptic encephalopathy (SCN2A-DEE), a severe and fatal monogenic epilepsy disorder caused by variations in the SCN2A gene.

Beclanorsen is an antisense oligonucleotide that specifically targets Bcl-2 mRNA.