T2167

lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.

3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifically inhibits analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase with IC50 of 2 μM. 3MB-PP1 can be used for the research of cell division and hypha formation of Candida albicans.

4-Bromo-N-methylbutan-1-amine hydrobromide is a PROTAC linker utilized for synthesizing PROTAC molecules.

1-Bromo-4-(3-bromopropyl)benzene is a PROTAC linker utilized in the synthesis of PROTAC molecules.

2-(3-((Tert-butoxycarbonyl)amino)cyclobutyl)acetic acid is a PROTAC linker useful for synthesizing PROTAC molecules.

DNPH1 ligand-1 (Compound 58) is a ligand for DNPH1. It serves as a target protein ligand (Ligands for Target Protein for PROTAC) and is utilized in the development and design of PROTACDNPH1 degraders. Additionally, DNPH1 ligand-1 is used in the synthesis of PROTACDNPH1 Degrader 1.

(S,S,S)-Me-AHPC-amide-C3-alkyne is an E3ligaseligand-linker conjugate designed for synthesizing (S)-JWZ-5-13.

CRBN ligand-512 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to recruit the cereblon protein. It can be linked to a target protein ligand via a linker to form a PROTAC.

6-(((Benzyloxy)carbonyl)amino)hexyl 4-methylbenzenesulfonate is a PROTAC linker used in the synthesis of PROTAC molecules.

Methyl 2-(3-(2-hydroxyethyl)bicyclo[1.1.1]pentan-1-yl)acetate is a PROTAC linker suitable for the synthesis of PROTAC molecules.

2,5-Dioxopyrrolidin-1-yl 3-((tert-butoxycarbonyl)amino)propanoate (Boc-Beta-Ala-OSu) is a PROTAC linker utilized in the synthesis of PROTAC molecules.

1,6-Diiodohexane is a PROTAC linker used in the synthesis of PROTAC molecules.

Midodrine hydrochloride ((±)-Midodrine hydrochloride) is an α1-receptor agonist used in the treatment of dysautonomia and orthostatic hypotension.

CRBN ligand-373 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), utilized for the recruitment of cereblon proteins. This compound can be conjugated to a target protein ligand through a linker to form a PROTAC.

CRBN ligand-208 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of cereblon proteins. It can be connected to a target protein ligand via a linker to form a PROTAC.

Octa-1,7-diyne is a PROTAC linker used for synthesizing PROTAC molecules.

2-((1-(tert-Butoxycarbonyl)azetidin-3-yl)oxy)acetic acid is a PROTAC linker used in the synthesis of PROTAC molecules.

tert-Butyl but-3-yn-1-ylcarbamate is a PROTAC linker utilized in the synthesis of PROTAC molecules.

2-(4-((tert-Butoxycarbonyl)amino)cyclohexyl)acetic acid is a PROTAC linker employed in the synthesis of PROTAC molecules.

4-Ethoxycarbonylmethylphenylboronic acid pinacol ester is a PROTAC linker used in the synthesis of PROTAC molecules.

CRBN ligand-871 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), utilized to recruit cereblon proteins. Through a linker, CRBN ligand-871 can attach to a target protein ligand to form a PROTAC.

CRBN ligand-514 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) and is used to recruit cereblon protein. It can be connected to a target protein ligand via a linker to form a PROTAC.

Thalidomide-piperazine-C-pyrrolidine dihydrochloride is an E3 ligase ligand-linker conjugate, consisting of a CRBN-based ligand and a linker, suitable for PROTAC synthesis.

4-(2-Propynyloxy)benzaldehyde is a PROTAC linker used in the synthesis of PROTAC molecules.