Search Result

Search Results for " pyroptosis "

Targets

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T11828	LDC7559		Pyroptosis
	LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage.		Pyroptosis
T0054	Disulfiram	Tetraethylthiuram disulfide,NSC 190940,TETD	Dehydrogenase , Interleukin , Pyroptosis
	Disulfiram (TETD) is an inhibitor of the acetaldehyde dehydrogenase ALDH, inhibiting hALDH1 and hALDH2 (IC50=0.15/1.45 μM) with specificity. Disulfiram is acutely sensitized to alcohol and also inhibits GSDMD pore format...		Dehydrogenase , Interleukin , Pyroptosis
T28178	NLRP3-IN-9	INF-4E,INF 4E,INF4E	NOD
	NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- ...		NOD
T0948	Adrenalone hydrochloride	Adrenalone HCl	Adrenergic Receptor
	Adrenalone hydrochloride (Adrenalone HCl) is a dopamine β-oxidase inhibitor with a similar structure to the norepinephrine transporter (NET) ligand, with an IC50 of 36.9 μM. It is an adrenergic agonist that acts as a loc...		Adrenergic Receptor
T28281	OXSI-2	OXSI 2,Syk Inhibitor	Syk
	OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets.		Syk
T24115	GSK854	GSK-854,GSK 854	Apoptosis
	GSK854 is a highly selective and potent inhibitor of troponin I interacting kinase (TNNI3K) that inhibits myocardial infarction-injured cellular pyroptosis and apoptosis in mice, which may limit oxidative stress, injury,...		Apoptosis
T60404	NLRP3/AIM2-IN-2		AIM2
	NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent pyroptosis with IC50 of 0.2392 ± 0.0233 μ M.		AIM2
T36347	Ac-YVAD-CMK	Caspase-1 Inhibitor II,Ac-Tyr-Val-Ala-Asp-chloromethylketone,Ac-Tyr-Val-Ala-Asp-CMK	IL Receptor , Caspase , Immunology/Inflammation related , Pyroptosis
	Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.
T76251L	Ac-FEID-CMK TFA		Pyroptosis
	Ac-FEID-CMK TFA is a selective zebrafish GSDMEb-derived peptide inhibitor that reduces mortality and renal injury in infectious shock.Ac-FEID-CMK TFA inhibits pyroptosis in vivo, attenuates septic AKI (acute kidney injur...		Pyroptosis
T6904	Necrosulfonamide	(E)-Necrosulfonamide	MLK
	(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during nec...		MLK
T80729	ZIKV-IN-6
	ZIKV-IN-6 (compound 22) acts as a direct inhibitor of the Zika virus (ZIKV) by binding to its RNA-dependent RNA polymerase (RdRp) and obstructing viral RNA synthesis mediated by the ZIKV NS5 protein. This compound also d...
T74922	ICy-OH
	ICy-OH, a iodinated photosensitizer, serves as a potent anticancer agent, capable of deep tissue imaging (λ ex =640 nm, λ em =690-740 nm) and selectively triggering cell death in pancreatic cancer cells through the cell ...
T80052	Cathepsin B
	Cathepsin B, a cysteine protease, plays a role in various forms of programmed cell death, such as apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death [1].
T74923	ICy-Q		Pyroptosis
	ICy-Q, a near-infrared (NIR) reagent activated by quinone oxidoreductase 1 (NQO-1), interacts with NQO-1 to yield the reduced product ICy-OH. This derivative selectively triggers pyroptosis and resultant death in pancrea...		Pyroptosis
T78822	JT002		NOD-like Receptor (NLR)
	JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1β, IL-1α, IL-18) and pyroptosis, as well as inhibits the formation of the NLR...		NOD-like Receptor (NLR)
T78894	NLRP3-IN-21		NOD-like Receptor (NLR)
	NLRP3-IN-21 (compound L38) is an inhibitor of the NLRP3 inflammasome that possesses anti-inflammatory properties. It suppresses the activation of the NLRP3 inflammasome and pyroptosis by inhibiting gasdermin D cleavage, ...		NOD-like Receptor (NLR)
T76273	Pep19-2.5
	Pep19-2.5, a synthetic antitoxin peptide, inhibits the intracellular signaling cascade triggered by endotoxins by blocking the activity of lipopeptides (LP) and lipopolysaccharides (LPS) mediated through both transmembra...
T82621	D359-0396		NOD-like Receptor (NLR)
	D359-0396 is an orally active NLRP3 inflammasome inhibitor that mitigates pyroptosis and reduces IL-1β release in macrophages by inhibiting the oligomerization of NLRP3, ASC, and the cleavage of GSDMD. This compound is e...		NOD-like Receptor (NLR)
T79695	NLRP3-IN-19	NLRP3-IN-19	NOD-like Receptor (NLR)
	JT001 (NLRP3-IN-19) is a potent, specific, and orally active NLRP3 inhibitor that impedes the assembly of the NLRP3 inflammasome. This action results in the suppression of cytokine release and prevention of pyroptosis. J...		NOD-like Receptor (NLR)
T76251	Ac-FEID-CMK
	Ac-FEID-CMK, a potent peptide inhibitor derived from zebrafish-specific GSDMEb, effectively reduces mortality and kidney injury during septic shock by inhibiting pyroptosis and mitigating acute kidney injury (AKI) in viv...
T79446	INF200		NOD-like Receptor (NLR)
	INF200 (compound 5), a sulfonylurea-based inhibitor of NLRP3 and associated pyroptosis, exhibits cardiometabolic benefits in a rat model of high-fat diet (HFD)-induced metaflammation and demonstrates anti-inflammatory ef...		NOD-like Receptor (NLR)
T79696	JT001 sodium	NLRP3-IN-19 sodium	NOD-like Receptor (NLR)
	JT001 (NLRP3-IN-19) sodium is a potent, specific, and orally active NLRP3 inhibitor that impedes the assembly of the NLRP3 inflammasome, thus curbing cytokine release and averting pyroptosis. It is utilized in research f...		NOD-like Receptor (NLR)
T79557	Fac-[Re(CO)3(L6)(H2O)][NO3]		Apoptosis
	Compound 6, fac-[Re(CO)3(L6)(H2O)][NO3], a rhenium(I) tricarbonyl aqua complex, serves as an anticancer agent by disrupting mitochondrial function. It exhibits cytotoxicity against prostate cancer cells with an IC50 of 5...		Apoptosis
T79743	Caspase-3 activator 1		Pyroptosis
	Caspase-3 activator 1 (compound 4b), a Ru(III) metal complex, effectively inhibits gastric tumor growth and metastasis by mediating caspase-3 cleavage. This cleavage enables Caspase-3 to process gasdermin E (GSDME), whic...		Pyroptosis
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 ...
T83889	C-02
	C-02, a proteolysis-targeting chimera (PROTAC) that combines the hexokinase inhibitor lonidamine with the cereblon ligand thalidomide, effectively induces the degradation of hexokinase 2 in 786-O and PANC-1 cells at a co...
T38309	LL-37 amide (trifluoroacetate salt)
	LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D...

Compounds

Synonym: Tetraethylthiuram disulfide,NSC 190940,TETD

Target: Dehydrogenase, Interleukin, Pyroptosis

NLRP3-IN-9

T28178

Synonym: INF-4E,INF 4E,INF4E

Target: NOD

Adrenalone hydrochloride

T0948

Synonym: Adrenalone HCl

Target: Adrenergic Receptor

OXSI-2

T28281

Synonym: OXSI 2,Syk Inhibitor

Target: Syk

GSK854

T24115

Synonym: GSK-854,GSK 854

Synonym: Caspase-1 Inhibitor II,Ac-Tyr-Val-Ala-Asp-chloromethylketone,Ac-Tyr-Val-Ala-Asp-CMK

Target: IL Receptor, Caspase, Immunology/Inflammation related, Pyroptosis

Synonym: (E)-Necrosulfonamide

Target: NOD-like Receptor (NLR)

NLRP3-IN-21

T78894

Synonym:

Target: NOD-like Receptor (NLR)

Target: NOD-like Receptor (NLR)

NLRP3-IN-19

T79695

Synonym: NLRP3-IN-19

Target: NOD-like Receptor (NLR)

Target: NOD-like Receptor (NLR)

JT001 sodium

T79696

Synonym: NLRP3-IN-19 sodium

Target: NOD-like Receptor (NLR)

fac-[Re(CO)3(L6)(H2O)][NO3]

T79557

Synonym:

Target: Apoptosis

Caspase-3 activator 1

LL-37 amide (trifluoroacetate salt)

T38309

Synonym:

Target:

Cat No.	Product Name	Targets
T6S2315	Polyphyllin VI	Apoptosis , Antibacterial , Pyroptosis
	1. Polyphyllin VI has hemostasis , expectorant , bacteriostasis, anticytotoxic, anti pregnancy kill sperm effects.	Apoptosis , Antibacterial , Pyroptosis
T3414	Morroniside	Apoptosis , MMP , Pyroptosis
	Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal damage and human umbilical vein endothelial cells, by inhib...	Apoptosis , MMP , Pyroptosis

Natural Products

Polyphyllin VI

T6S2315

Synonym:

Target: Apoptosis, Antibacterial, Pyroptosis

Morroniside

T3414

Synonym:

Target: Apoptosis, MMP, Pyroptosis

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01376	Gasdermin-C Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death.; Pore-forming protein th...
TMPH-01375	Gasdermin-C Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death.; Pore-forming protein th...
TMPH-01057	Caspase-8 Protein, Human, Recombinant (His)	Human	E. coli
	Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood...
TMPH-01374	Gasdermin-B Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasd...
TMPH-02670	Gasdermin-A3 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Precursor of a pore-forming protein involved in the transition from catagen to telogen at the end of hair follicle morphogenesis. This form constitutes the precursor of the pore: upon cleavage, the released N-terminal mo...
TMPH-02671	Gasdermin-D Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-term...
TMPH-02687	Granzyme A/GZMA Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or ...
TMPH-01055	Caspase-1 Protein, Human, Recombinant (HA)	Human	E. coli
	Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well ...
TMPH-01738	NLRP1 Protein, Human, Recombinant (GST)	Human	E. coli
	Acts as the sensor component of the NLRP1 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis. Inflammasomes are supramolecular comple...
TMPH-01739	NLRP3 Protein, Human, Recombinant (His)	Human	E. coli
	As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polym...
TMPH-02521	PYCARD Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mit...

Gasdermin-C Protein, Human, Recombinant (His & SUMO)

TMPH-01376

Species: Human

Expression System: E. coli

Gasdermin-C Protein, Human, Recombinant (His & Myc)

TMPH-01375

Species: Human

Expression System: Baculovirus

Caspase-8 Protein, Human, Recombinant (His)

TMPH-01057

Species: Human

Expression System: E. coli

Gasdermin-B Protein, Human, Recombinant (His & Myc)

TMPH-01374

Species: Human

Expression System: E. coli

Gasdermin-A3 Protein, Mouse, Recombinant (His)

TMPH-02670

Species: Mouse

Expression System: E. coli

Gasdermin-D Protein, Mouse, Recombinant (His & Myc)

TMPH-02671

Species: Mouse

Expression System: E. coli

Granzyme A/GZMA Protein, Mouse, Recombinant (His)

TMPH-02687

Species: Mouse

Expression System: E. coli

Caspase-1 Protein, Human, Recombinant (HA)

TMPH-01055

Species: Human

Expression System: E. coli

NLRP1 Protein, Human, Recombinant (GST)

TMPH-01738

Species: Human

Expression System: E. coli

NLRP3 Protein, Human, Recombinant (His)

TMPH-01739

Species: Human

Expression System: E. coli

PYCARD Protein, Mouse, Recombinant (His & Myc)

TMPH-02521

Species: Mouse

Expression System: E. coli

Cat No.	Product Name
L8720	Pyroptosis Compound Library	1077 compounds
	1077 types of active small molecules associated with pyroptosis for high-throughput and high-content screening.
L8710	Cuproptosis Compound Library	411 compounds
	TargetMol’s Cuproptosis Compound Library is a collection of 411 compounds related to copper-dependent death that can be used to study its mechanism and related diseases.

Libraries

Pyroptosis Compound Library

L8720

Compounds: 1077

Cuproptosis Compound Library

L8710

Compounds: 411