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Search Results for " porcupine "

Targets

12

Compounds

Cat No. Product Name Synonyms Targets
T4438 Porcn-IN-1 Porcupine-IN-1 Porcupine
Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
T5342 IWP-O1 Wnt/beta-catenin , Porcupine
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
T2702 IWP-2 IWP2 Casein Kinase , Wnt/beta-catenin , Porcupine
IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
T4043 ETC-159 ETC159,ETC-1922159,ETC 159 Wnt/beta-catenin , Porcupine
ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
T2618 LGK974 LGK 974,LGK-974,NVP-LGK974,WNT974 Porcupine
LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cel...
T2683 IWP L6 Porcn Inhibitor III,IWP-L6,Porcn Inhibitor III Porcupine
IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
T2242 Wnt-C59 C59 Wnt/beta-catenin , Porcupine
Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.
T11444 GNF-6231 Porcupine
GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
T77780 Zamaporvint RXC004 Others
Zamaporvint (RXC004) is a selective, orally active and potent inhibitor of the Wnt pathway that acts on the membrane-bound fatty acyltransferase porcupine to block Wnt ligand palmitoylation, secretion, and pathway activa...
T22875 IWP 12 Others
Potent inhibitor of Porcupine (PORCN)
T31983 GNF-1331 GNF 1331
GNF-1331 is a potent, selective, and orally bioavailable porcupine inhibitor (IC50 = 12 nM). Blocking abnormal Wnt signaling is an attractive treatment for a variety of cancers.
T21650 IWP-3
IWP-3 is an potent inhibitor of Wnt production with an IC 50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 moderately inhibits CK1γ3 and CK1ε while not inhibit...
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