12
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4438 | Porcn-IN-1 | Porcupine-IN-1 | Porcupine |
Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM). | |||
T5342 | IWP-O1 | Wnt/beta-catenin , Porcupine | |
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. | |||
T2702 | IWP-2 | IWP2 | Casein Kinase , Wnt/beta-catenin , Porcupine |
IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation. | |||
T4043 | ETC-159 | ETC159,ETC-1922159,ETC 159 | Wnt/beta-catenin , Porcupine |
ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM. | |||
T2618 | LGK974 | LGK 974,LGK-974,NVP-LGK974,WNT974 | Porcupine |
LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cel... | |||
T2683 | IWP L6 | Porcn Inhibitor III,IWP-L6,Porcn Inhibitor III | Porcupine |
IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM). | |||
T2242 | Wnt-C59 | C59 | Wnt/beta-catenin , Porcupine |
Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity. | |||
T11444 | GNF-6231 | Porcupine | |
GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling. | |||
T77780 | Zamaporvint | RXC004 | Others |
Zamaporvint (RXC004) is a selective, orally active and potent inhibitor of the Wnt pathway that acts on the membrane-bound fatty acyltransferase porcupine to block Wnt ligand palmitoylation, secretion, and pathway activa... | |||
T22875 | IWP 12 | Others | |
Potent inhibitor of Porcupine (PORCN) | |||
T31983 | GNF-1331 | GNF 1331 | |
GNF-1331 is a potent, selective, and orally bioavailable porcupine inhibitor (IC50 = 12 nM). Blocking abnormal Wnt signaling is an attractive treatment for a variety of cancers. | |||
T21650 | IWP-3 | ||
IWP-3 is an potent inhibitor of Wnt production with an IC 50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 moderately inhibits CK1γ3 and CK1ε while not inhibit... |