Mitomycin A

Mitomycin A is a cytotoxic antibiotic derived from Streptomyces sp. with anticancer activity and antitumor activity.Mitomycin A is used in the study of solid cancers.

7-N-(4-Hydroxyphenyl)mitomycin C is a bioactive chemical.

BMY-25551, a Mitomycin A analog, exhibits cytotoxicity 8 to 20 times greater than Mitomycin C against both murine and human tumor cell lines. It is applicable in research pertaining to cancer and hematological disorders.

Apaziquone (EOquin, EO9) is an indolequinone compound that acts as a bioreductive prodrug. It is chemically similar to the earlier chemotherapy compound mitomycin C.

Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.

RM 49 is a mitomycin C derivative that has antitumor activity in vitro.

KW 2149 is a compound derived from mitomycin C.

Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fluorouracil , cisplatin , bleomycin , mitomycin C , and 6-mercaptopurine. It is an oxidized form of ansatrienin B .

Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 300 nM). Early in vitro studies showed that ansatrienin B potentiates the chemotherapeutic action of 5-fluorouracil , cisplatin , bleomycin , mitomycin C , and 6-mercaptopurine. Ansatrienin B is a hydroquinone form of ansatrienin A .

Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells.

Mitomycin C (Ametycine) is an antineoplastic agent and DNA double-strand crosslinking agent capable of inducing DNA damage, inhibiting DNA synthesis, suppressing mitosis, and activating apoptosis. Mitomycin C is a broad-spectrum antibiotic against both Gram-negative and Gram-positive bacteria.

Gentisuric acid, an Aspirin metabolite and a substrate of α-amidating monooxygenase (PAM), mitigates DNA damage induced by Mitomycin C. [1] [2]

3-Amino-5-hydroxybenzoic acid-13C is the 13C-labeled version of 3-Amino-5-hydroxybenzoic acid. This compound, also known as AHBA, serves as a biosynthetic precursor to the mC7N unit of ansamycin class antibiotics, including ansamitocin and geldanamycin, as well as the antitumor antibiotic mitomycin C. It is likely derived from an early intermediate in the shikimic acid pathway originating from glucose.

Mitomycin C-[13C,15N2] (Standard) is a reference standard of Mitomycin C-[13C,15N2] intended for quantitative analysis, quality control, and related biochemical research applications.

10-Decarbamoyloxy-9-dehydromitomycin B is a type of mitomycin, characterized by its antibacterial and antitumor properties.