Home Tools
Log in
Cart

Search Result

Search Results for " glucokinase "

Targets

34

Compounds

3

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T11418 Glucokinase activator 1 Others
Glucokinase activator 1 is a liver-directed glucokinase activator (EC50: 34 nM).
T72284 Glucokinase activator 3
Glucokinase Activator 3, a highly potent and complete activator of Glucokinase (GK), exhibits an AC50 value of 38 nM. This compound holds potential for type 2 diabetes research applications.
TQ0055 AMG-3969 Glucokinase
AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).
T16479 PF-04937319 Others , Glucokinase
PF-04937319 is an activator of glucokinase (EC50 =154.4  μM). PF-04937319 maintains glucose-lowering efficacy while mitigating the risk of hypoglycemia observed with many other glucokinase activators. PF-04937319 can be ...
T3312 AM-2394 AM2394 Glucokinase
AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximatel...
T3104 Globalagliatin LY2608204 Glucokinase
Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
T26712 AZD-1656 AZD 1656 Glucokinase
AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2 diabetes.
T15159 Dorzagliatin HMS5552 Glucokinase
Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.
T12056 MK-0941 free base Glucokinase
MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.
T68762 LY-2599506
LY-2599506 is a novel glucokinase activator.
T30142 ARRY-403 AMG-151,ARRY 403,ARRY403,ARRY-403,AMG151,AMG 151 Glucokinase
ARRY-403 is a novel glucokinase activator that reduces fasting and postprandial blood glucose in patients with type 2 diabetes.
T77784 WAY-297848 Glucokinase
WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.
T3104L (1S,2R)-Globalagliatin (1S,2R)-Globalagliatin(1S,2R-1234703-40-2) Glucokinase
(1S,2R)-Globalagliatin is a highly potent glucokinase (GK) activator for the study of type 2 diabetes.
T14212 AMG-1694 Glucokinase
AMG-1694, a potent disruptor of the glucokinaseglucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of...
T23765 AZD1092 AZD 1092,AZD-1092
AZD1092 is the glucokinase enzyme activator.
T25452 GKA-71 GKA 71
GKA-71 is an effective glucokinase activator (GKA).
T64046 BMS-820132
BMS-820132 is a glucokinase activator (AC50: 29 nM).
T32612 LBX192 NVP-LBX-192,LBX-192,LBX 192,NVP-LBX192,NVP-LBX 192
LBX192( NVP-LBX192) is a liver-targeted glucokinase activator.
T29974 AMG-7549
AMG-7549 is a disrupter of GlucokinaseGlucokinase Regulatory Protein (GK−GKRP) binding.
T25451 GKA-22 GKA22,GKA 22
GKA-22 is a human glucokinase allosteric activator in the absence of glucose.
T28781 Sinogliatin HMS-5552,RO 5305552,HMS5552,RO5305552,HMS 5552,RO-5305552
Sinogliatin, a glucokinase activator, is used potentially for the treatment of type 2 diabetes.
T10092 PSN-GK1 Others
PSN-GK1 is a potent activator of glucokinase (EC50: 0.13 μM).
T12057 MK-0941 Others
MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes.
T68244 PF-04279405
PF-04279405 is a potent and selective glucokinase activator.
T16480 PF-04991532 Glucokinase
PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM in human and rat, respectively.
T10362 AR453588 Others
AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.
T10362L AR453588 hydrochloride Others
AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.
T70639 AM-9514
AM-9514 is a novel, potent Glucokinase (GK) activator. AM-9514 showed a favorable combination of in vitro potency, enzyme kinetic properties, acceptable pharmacokinetic profiles in preclinical species, and robust effica...
T11401 GKA50 Others
GKA50 stimulates insulin release from mouse islets of Langerhans and MIN6 cells. GKA50 shows significant glucose lowering in high fat fed female rats. GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose).
T72743 (R)-PF-04991532
(R)-PF-04991532 is the R-enantiomer of PF-04991532 . PF-04991532 is a potent, hepatoselective glucokinase activator .
T68976 Piragliatin
Piragliatin, also known as RO4389620, is a glucokinase activator. Piragliatin greatly enhances glucose-induced pancreatic islet respiration and insulin release. Piragliatin lowers plasma glucose both in the postabsorptiv...
T26718 AZD6370 AZD-6370,AZD 6370
AZD-6370 is a glucokinase activator. AZD-6370 decreases fasting and postprandial glucose in type 2 diabetes mellitus patients with effects influenced by dosing regimen and food. AZD-6370 do not affect the central counter...
T70391 AMG151 HCl
ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics an...
T63019 GKA50 quarterhydrate
GKA50 quarterhydrate is a potent glucokinase activator with an EC50 value of 33 nM. GKA50 quarterhydrate is a glucose-like activator of β-cell metabolism in rodent and human pancreatic islets and a Ca2+-dependent regulat...

Compounds

Glucokinase activator 1
T11418
Synonym:
Target: Others
Glucokinase activator 3
T72284
Synonym:
Target:
AMG-3969
TQ0055
Synonym:
Target: Glucokinase
PF-04937319
T16479
Synonym:
Target: Others, Glucokinase
AM-2394
T3312
Synonym: AM2394
Target: Glucokinase
Globalagliatin
T3104
Synonym: LY2608204
Target: Glucokinase
AZD-1656
T26712
Synonym: AZD 1656
Target: Glucokinase
Dorzagliatin
T15159
Synonym: HMS5552
Target: Glucokinase
MK-0941 free base
T12056
Synonym:
Target: Glucokinase
LY-2599506
T68762
Synonym:
Target:
ARRY-403
T30142
Synonym: AMG-151,ARRY 403,ARRY403,ARRY-403,AMG151,AMG 151
Target: Glucokinase
WAY-297848
T77784
Synonym:
Target: Glucokinase
(1S,2R)-Globalagliatin
T3104L
Synonym: (1S,2R)-Globalagliatin(1S,2R-1234703-40-2)
Target: Glucokinase
AMG-1694
T14212
Synonym:
Target: Glucokinase
AZD1092
T23765
Synonym: AZD 1092,AZD-1092
Target:
GKA-71
T25452
Synonym: GKA 71
Target:
BMS-820132
T64046
Synonym:
Target:
LBX192
T32612
Synonym: NVP-LBX-192,LBX-192,LBX 192,NVP-LBX192,NVP-LBX 192
Target:
AMG-7549
T29974
Synonym:
Target:
GKA-22
T25451
Synonym: GKA22,GKA 22
Target:
Sinogliatin
T28781
Synonym: HMS-5552,RO 5305552,HMS5552,RO5305552,HMS 5552,RO-5305552
Target:
PSN-GK1
T10092
Synonym:
Target: Others
MK-0941
T12057
Synonym:
Target: Others
PF-04279405
T68244
Synonym:
Target:
PF-04991532
T16480
Synonym:
Target: Glucokinase
AR453588
T10362
Synonym:
Target: Others
AR453588 hydrochloride
T10362L
Synonym:
Target: Others
AM-9514
T70639
Synonym:
Target:
GKA50
T11401
Synonym:
Target: Others
(R)-PF-04991532
T72743
Synonym:
Target:
Piragliatin
T68976
Synonym:
Target:
AZD6370
T26718
Synonym: AZD-6370,AZD 6370
Target:
AMG151 HCl
T70391
Synonym:
Target:
GKA50 quarterhydrate
T63019
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T19500 Palmitelaidic Acid trans-Palmitoleic acid,9-trans-Hexadecenoic acid Glucokinase , AMPK , PPAR
Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.
T4726 D-Glucose 6-phosphate sodium G6P sodium salt,D-Glucose 6-phosphate sodium salt,Sodium Glucose-6-Phosphate Others , Endogenous Metabolite
In cells, D-glucose 6-phosphate (G6P) is generated when glucose is phosphorylated by hexokinase or glucokinase or by the conversion of glucose-1-phosphate by phosphoglucomutase during glycogenolysis. G6P lies at the begi...
T5069 D-Glucose 6-phosphate potassium salt Others
D-Glucose 6-phosphate potassium is the potassiu salt form of D-glucose 6-phosphate, which is a glucose sugar phosphorylated at the hydroxy group on carbon 6.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-04394 Glucokinase Protein, Human, Recombinant Human E. coli
Glucokinase belongs to the bacterial glucokinase family. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in ...
TMPH-01387 GCKR Protein, Human, Recombinant (His) Human Yeast
Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a me...
TMPH-01388 GCKR Protein, Human, Recombinant (His & SUMO) Human E. coli
Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a me...
TargetMol