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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11418 | Glucokinase activator 1 | Others | |
Glucokinase activator 1 is a liver-directed glucokinase activator (EC50: 34 nM). | |||
T72284 | Glucokinase activator 3 | ||
Glucokinase Activator 3, a highly potent and complete activator of Glucokinase (GK), exhibits an AC50 value of 38 nM. This compound holds potential for type 2 diabetes research applications. | |||
TQ0055 | AMG-3969 | Glucokinase | |
AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM). | |||
T16479 | PF-04937319 | Others , Glucokinase | |
PF-04937319 is an activator of glucokinase (EC50 =154.4 μM). PF-04937319 maintains glucose-lowering efficacy while mitigating the risk of hypoglycemia observed with many other glucokinase activators. PF-04937319 can be ... | |||
T3312 | AM-2394 | AM2394 | Glucokinase |
AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximatel... | |||
T3104 | Globalagliatin | LY2608204 | Glucokinase |
Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2. | |||
T26712 | AZD-1656 | AZD 1656 | Glucokinase |
AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2 diabetes. | |||
T15159 | Dorzagliatin | HMS5552 | Glucokinase |
Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes. | |||
T12056 | MK-0941 free base | Glucokinase | |
MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes. | |||
T68762 | LY-2599506 | ||
LY-2599506 is a novel glucokinase activator. | |||
T30142 | ARRY-403 | AMG-151,ARRY 403,ARRY403,ARRY-403,AMG151,AMG 151 | Glucokinase |
ARRY-403 is a novel glucokinase activator that reduces fasting and postprandial blood glucose in patients with type 2 diabetes. | |||
T77784 | WAY-297848 | Glucokinase | |
WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome. | |||
T3104L | (1S,2R)-Globalagliatin | (1S,2R)-Globalagliatin(1S,2R-1234703-40-2) | Glucokinase |
(1S,2R)-Globalagliatin is a highly potent glucokinase (GK) activator for the study of type 2 diabetes. | |||
T14212 | AMG-1694 | Glucokinase | |
AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of... | |||
T23765 | AZD1092 | AZD 1092,AZD-1092 | |
AZD1092 is the glucokinase enzyme activator. | |||
T25452 | GKA-71 | GKA 71 | |
GKA-71 is an effective glucokinase activator (GKA). | |||
T64046 | BMS-820132 | ||
BMS-820132 is a glucokinase activator (AC50: 29 nM). | |||
T32612 | LBX192 | NVP-LBX-192,LBX-192,LBX 192,NVP-LBX192,NVP-LBX 192 | |
LBX192( NVP-LBX192) is a liver-targeted glucokinase activator. | |||
T29974 | AMG-7549 | ||
AMG-7549 is a disrupter of Glucokinase−Glucokinase Regulatory Protein (GK−GKRP) binding. | |||
T25451 | GKA-22 | GKA22,GKA 22 | |
GKA-22 is a human glucokinase allosteric activator in the absence of glucose. | |||
T28781 | Sinogliatin | HMS-5552,RO 5305552,HMS5552,RO5305552,HMS 5552,RO-5305552 | |
Sinogliatin, a glucokinase activator, is used potentially for the treatment of type 2 diabetes. | |||
T10092 | PSN-GK1 | Others | |
PSN-GK1 is a potent activator of glucokinase (EC50: 0.13 μM). | |||
T12057 | MK-0941 | Others | |
MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes. | |||
T68244 | PF-04279405 | ||
PF-04279405 is a potent and selective glucokinase activator. | |||
T16480 | PF-04991532 | Glucokinase | |
PF-04991532 is an effective, hepatoselective glucokinase activator. It has EC50s of 80 and 100 nM in human and rat, respectively. | |||
T10362 | AR453588 | Others | |
AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity. | |||
T10362L | AR453588 hydrochloride | Others | |
AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity. | |||
T70639 | AM-9514 | ||
AM-9514 is a novel, potent Glucokinase (GK) activator. AM-9514 showed a favorable combination of in vitro potency, enzyme kinetic properties, acceptable pharmacokinetic profiles in preclinical species, and robust effica... | |||
T11401 | GKA50 | Others | |
GKA50 stimulates insulin release from mouse islets of Langerhans and MIN6 cells. GKA50 shows significant glucose lowering in high fat fed female rats. GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose). | |||
T72743 | (R)-PF-04991532 | ||
(R)-PF-04991532 is the R-enantiomer of PF-04991532 . PF-04991532 is a potent, hepatoselective glucokinase activator . | |||
T68976 | Piragliatin | ||
Piragliatin, also known as RO4389620, is a glucokinase activator. Piragliatin greatly enhances glucose-induced pancreatic islet respiration and insulin release. Piragliatin lowers plasma glucose both in the postabsorptiv... | |||
T26718 | AZD6370 | AZD-6370,AZD 6370 | |
AZD-6370 is a glucokinase activator. AZD-6370 decreases fasting and postprandial glucose in type 2 diabetes mellitus patients with effects influenced by dosing regimen and food. AZD-6370 do not affect the central counter... | |||
T70391 | AMG151 HCl | ||
ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics an... | |||
T63019 | GKA50 quarterhydrate | ||
GKA50 quarterhydrate is a potent glucokinase activator with an EC50 value of 33 nM. GKA50 quarterhydrate is a glucose-like activator of β-cell metabolism in rodent and human pancreatic islets and a Ca2+-dependent regulat... |
Cat No. | Product Name | Synonyms | Targets |
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T19500 | Palmitelaidic Acid | trans-Palmitoleic acid,9-trans-Hexadecenoic acid | Glucokinase , AMPK , PPAR |
Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue. | |||
T4726 | D-Glucose 6-phosphate sodium | G6P sodium salt,D-Glucose 6-phosphate sodium salt,Sodium Glucose-6-Phosphate | Others , Endogenous Metabolite |
In cells, D-glucose 6-phosphate (G6P) is generated when glucose is phosphorylated by hexokinase or glucokinase or by the conversion of glucose-1-phosphate by phosphoglucomutase during glycogenolysis. G6P lies at the begi... | |||
T5069 | D-Glucose 6-phosphate potassium salt | Others | |
D-Glucose 6-phosphate potassium is the potassiu salt form of D-glucose 6-phosphate, which is a glucose sugar phosphorylated at the hydroxy group on carbon 6. |
Cat No. | Product Name | Species | Expression System |
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TMPY-04394 | Glucokinase Protein, Human, Recombinant | Human | E. coli |
Glucokinase belongs to the bacterial glucokinase family. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in ... | |||
TMPH-01387 | GCKR Protein, Human, Recombinant (His) | Human | Yeast |
Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a me... | |||
TMPH-01388 | GCKR Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a me... |