Cloxacillin

Cloxacillin, an orally active antibacterial agent and β-lactamase inhibitor, exhibits an IC50 of 0.04 µM. It effectively suppresses S. aureus-induced inflammatory responses by inhibiting the activation of MAPKs, NF-кB, and NLRP3-related proteins.

Cloxacillin sodium monohydrate (Cloxacillin Sodium) is the sodium salt of cloxaclliin, a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity.

Cloxacillin Sodium, a chlorinated derivative of Oxacillin, is a semi-synthetic antibiotic. Cloxacillin is used for the treatment of infections caused by species of staphylococci which produce beta-lactamase.

Flucloxacillin sodium (floxacillin sodium) is a highly active antibiotic against Gram-negative and Gram-positive bacteria.

Dicloxacillin Sodium hydrate is a narrow-spectrum β-Lactam antibiotic of the penicillin class, used to treat infections caused by susceptible Gram-positive bacteria.

Dicloxacillin (INN), a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used against beta-lactamase-producing organisms such as Staphylococcus aureus, which would otherwise be resistant to most penicillins.

Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive negative aerobic and anaerobic bacteria.

Flucloxacillin, an antibiotic, effectively combats both gram-positive and gram-negative bacteria [1] [2].

Antibioticadjuvant 1 (compound 3e) is an antibiotic adjuvant that exhibits insufficient antimicrobial activity on its own (MIC > 128 µg mL), yet significantly enhances the effectiveness of Cloxacillin, boosting its activity by 66 times, demonstrating a synergistic effect.