cdk-in-12 — TargetMol Chemicals

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Search Results for " cdk-in-12 "

Compounds

Cat No.	Product Name	Synonyms	Targets
T75127	CDK-IN-12
	CDK-IN-12 (Example 20), a CDK inhibitor, effectively inhibits CDK4/6, demonstrating IC50 values below 20 nM [1].
T39752	CDK12-IN-2	CDK12 inhibitor 2,CDK12-IN-2	CDK
	CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CD...		CDK
T39354	CDK9-IN-12	CDK9-IN-12
	CDK9-IN-12 displays the optimal CDK9 inhibitory activity with an IC 50 value of 5.41 nM.
T14915	CDK12-IN-E9		CDK
	CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak binding ability to CDK7/CyclinH complex (IC50> 1 μM).		CDK
T14990	CDK12-IN-3		CDK
	CDK12-IN-3 is a selective CDK12 inhibitor (IC50: 491 nM in an enzymatic assay).		CDK
T40288	CDK12-IN-4	CDK12-IN-4
	CDK12-IN-4, a pyrazolotriazine compound, exhibits potent inhibition of CDK12 by achieving an IC50 value of 0.641 μM, utilizing high ATP levels (2 mM). Notably, CDK12-IN-4 does not impact CDK2/Cyclin E (IC50 > 20 μM) or C...
T40290	CDK12-IN-5	CDK12-IN-5
	CDK12-IN-5 is a pyrazolotriazine compound that effectively inhibits CDK12, with an IC50 value of 23.9 nM at a high ATP concentration of 2 mM. However, CDK12-IN-5 does not exhibit inhibitory effects on CDK2/Cyclin E (IC50...
T40289	CDK12-IN-6	CDK12-IN-6
	CDK12-IN-6, a pyrazolotriazine compound, is a powerful inhibitor of CDK12. Its inhibitory activity is significant with an IC50 value of 1.19 μM when tested at high ATP concentration (2 mM). Notably, CDK12-IN-6 does not e...
T62926	CDK7/12-IN-1
	CDK7/12-IN-1 is a selective inhibitor of CDK7/12, acting on CDK7 (IC50: 3 nM) and CDK 12 (IC50: 277 nM). Inhibition of CDK7 and CDK12 is an effective inhibitor of tumour growth.