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Collagen, Type II (derived from bovine snout cartilage), is a homotrimeric helical protein composed of three identical α1(II) chains and is a major component of animal cartilage. It possesses multiple biological activities, including maintaining cartilage tissue integrity, inducing immune tolerance, and promoting chondrocyte growth and redifferentiation. It is commonly used to induce collagen-induced arthritis (CIA) models and has demonstrated significant efficacy in alleviating pain and inflammation associated with collagen-induced arthritis in mice, making it widely applicable in osteoarthritis-related research.