6 chloropurine

6-Chloropurine (6-Chloro-9H-purine) is a building block in chemical synthesis,with Antitumor activities.

2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).1 1.Qiu, Y.-L., Ksebati, M.B., Ptak, R.G., et al.(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activityJ. Med. Chem.41(1)10-23(1998)

9-(5(R)-C-Methyl-2,3,5-tri-O-benzoyl-D-ribofuranosyl)-6-chloropurine, a purine nucleoside analog, demonstrates broad antitumor activity, particularly against indolent lymphoid malignancies, through inhibition of DNA synthesis and induction of apoptosis. [1]

6-Chloropurine riboside (6-CPR) is a purine nucleoside analog that has been found to have a wide range of biological activities. It inhibits the growth of tumor cells and induces apoptosis. It has also been shown to have anti-inflammatory, antiviral and antifungal properties. It has also been found to be neuroprotective and has been used in the treatment of neurological disorders.

6-Chloropurine riboside-5'-triphosphate serves as both an inhibitor and an activator in biochemical processes. It inhibits the RNA triphosphatase mRNA-capping enzyme subunit β (Cet1; IC50 = 2 µM for the GTPase activity of the S. cerevisiae enzyme), proving its efficacy against the enzyme responsible for the capping of mRNA molecules. Additionally, it acts as a phosphorylated derivative of 6-chloropurine riboside. This compound also activates the E. coli enzyme aspartate carbamoyltransferase (EC50 = 0.76 mM), demonstrating its versatility in modulating enzyme activities. It is instrumental in the synthesis of cytokinins with anticancer properties and a photoclickable form of ATP, highlighting its applications in biochemical synthesis and potential therapeutic uses.

2-Amino-6-chloropurine-9-(2'-O-methyl)riboside is a Halo-nucleoside; 2'-O-Methyl nucleoside.

2-Amino-6-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside is a Fluoro-modified nucleoside; Halo-nucleoside; Arabino-nucleoside.

2-Amino-6-chloropurine -9-beta-D-(2'-deoxy-3',5'-di-O-benzoyl-2'-fluoro)arabinoriboside is a fluoro-modified nucleoside, halo-nucleoside, and arabino-nucleoside.

6-Chloropurine -9-beta-D-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro)arabinoriboside is a Fluoro-modified nucleoside; Halo-nucleoside; Arabino-nucleoside.

2-Amino-6-chloropurine-9-beta-D-(2'-deoxy-3',5'-di-(O-p-toluoyl))riboside is a 2'-deoxy nucleoside and halo-nucleoside.

2-Amino-6-chloropurine-9-beta-D-(2'-deoxy)riboside is a 2'-deoxy nucleoside and halo-nucleoside.

9-(2'-O-Acetyl-5'-O-benzoyl-3'-deoxy-beta-D-ribofuranosyl)-6-chloropurine is a Nucleoside Derivative used as a 3'-Deoxy nucleoside, Halo-nucleoside, scaffold, and template.

9-(5(R)-C-Methyl-2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-6-chloropurine is a useful organic compound for research related to life sciences and the catalog number is TNU0992.

3,5-O-Ditoluoyl 6-chloropurine-9-β-D-deoxyriboside is a nucleoside derivative classified under other modified nucleosides.

(S)-9-(2,3-Dihydroxypropyl)-2-amino-6-chloropurine is a Nucleoside Derivative - Acyclic nucleoside.

9-(2,5-Di-O-benzoyl-2-C-beta-ethynyl-beta-D-ribofuranosyl)-6-chloropurine is a useful organic compound for research related to life sciences and the catalog number is TNU1616.

9-(2,3-Di-O-acetyl-6-O-benzoyl-5-deoxy-D-ribo-exofuranoyl)-6-chloropurine is an organic compound useful for life sciences research (catalog number: TNU1673).

Nucleoside Derivatives - 2'-Modified nucleosides, Halo-nucleosides; Scaffolds and Templates

Nucleoside - 2'-deoxy nucleoside; halo nucleoside

Nucleosides - 3'-O-methyl nucleoside; halo-nucleoside

Fluoro-modified nucleoside; Halo-nucleoside

Sorafenib (Bay 43-9006) is a multikinase inhibitor that targets Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. It exhibits antitumor properties and can induce autophagy, apoptosis, and agonistic iron death.

Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces apoptosis.

Daraxonrasib (RMC-6236) is an orally effective and novel triple complex RAS (ON) MULTI inhibitor, which is a potent non covalent inhibitor of multiple RAS variants in GTP binding state. RMC-6236 has anti-tumor activity and can be used in research related to RAS driven tumors. With rich experience in compound synthesis, we can provide fast customized synthesis services for this product according to your research needs.