5hete

5(R)-HETE is a rare lipoxygenase product of arachidonic acid. Nearly all plant and animal 5-LOs produce 5(S)-HETE, but the presence of a 5(R)-LO and the synthesis of 5(R)-HpETE and 5(R)-HETE have been confirmed in oocytes of the bivalve mollusk, S. solidissima. 5(R)-HETE is more potent than the (S)-enantiomer as a chemotactic agent for human neutrophils.

5(S)-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of 5(S)-HETE. The ability of (±)5-HETE lactone to inhibit rat basophilic leukemia cell 5-lipoxygenase (IC50 = 27 μM) may be entirely due to the 5(S) isomer, but the enantiomers have not been tested separately.

Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraenoic acid (5-HETE) is 7.8 +/- 1.7 and

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Astragalus polyphenols) is a compound isolated from the roots of Polygonum species, which inhibits the formation of 5-HETE, HHT, and thromboxane B2.

5-HETE is a fatty acid metabolite and an oxidative derivative of arachidonic acid produced through lipoxygenase activity, existing as a racemic mixture of the 5(S)-HETE and 5(R)-HETE enantiomers, and it acts as a potent aggregating agent that induces the aggregation of human neutrophils with a IC50 value of approximately 200 nM.

(±)15-HETE is an eicosanoid compound that possesses intrinsic biological activities and serves as a key enzymatic precursor for the biosynthesis of numerous other biologically active lipid-derived derivatives; furthermore, this alkyl chain-based structure functions as a proteolysis-targeting chimera (PROTAC) linker utilized in the chemical synthesis of various PROTAC molecules designed for targeted protein degradation.

(±)5-HETE, a monohydroxy fatty acid, emerges from the non-enzymatic oxidation of arachidonic acid and is one of six such derivatives. Its methyl ester variant exhibits no unique biological activity and serves as a provided standard. This methyl ester can also be present in oxidatively degraded polyunsaturated fatty acid (PUFA) methyl esters.

15-HETE-CoA (15-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-coenzyme A) is a type of unsaturated acyl-coenzyme A.

5-Hete-CoA (5-Hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-coenzyme A) is an unsaturated acyl-coenzyme A.