5-ht3 antagonist 3

5-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist that binds to 5-HT3 receptors in rat brain cortical membranes (Ki: 0.25 nM).

5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound that acts as a 5-HT3 receptor antagonist, counteracting 5-HT3 agonist and 2-methyl-5-HT, and demonstrating an anti-depressant effect in mice [1].

5-HT3 antagonist 2 is an antagonist of 5-HT3 receptor.

5-HT3 antagonist 1 is a potent and selective inhibitor of the 5-HT3 receptor.

Granisetron hydrochloride (Granisetron HCl) is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.

Tropisetron hydrochloride (Tropisetron HCl) is the hydrochloride salt form of tropisetron, a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, with antinauseant and antiemetic activities.

3-AQC is a competitive antagonist of 5-HT3.

Ondansetron hydrochloride dihydrate (GR 38032) is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Batanopride (originally named BMY-25801) is a 5-HT3 receptor antagonist that has been utilized in research to address vomiting in cancer patients undergoing chemotherapy.

Scopolamine is a high-affinity (nanomolar level) muscarinic receptor antagonist that can reversibly inhibit 5-HT₃ receptor responses (IC₅₀ = 2.09 μM). It is commonly used to induce animal models of Alzheimer's disease or memory impairment.

FPPQ is a dual antagonist of the 5-HT3 and 5-HT6 receptors with Ki values of 0.9 nM and 3 nM, respectively, and exhibits antipsychotic and pro-cognitive activity.

Lerisetron is an antagonist of serotonin type 3 (5-HT3) receptor, with antiemetic activity.

GR65630 is an effective and selective antagonist of the 5-hydroxytryptamine (5-HT) type 3 receptor. It is utilized to investigate the expression patterns of 5-HT3 receptors across various brain regions and their potential functions in the central nervous system. Additionally, GR65630 and its radiolabeled form [3H]GR65630 are employed in studies examining receptor distribution, density, and affinity.

Palonosetron-d3 HCl is a deuterated compound of Palonosetron HCl. Palonosetron HCl has a CAS number of 135729-62-3. Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.