4 methylumbelliferyl 6 thio palmitate β d glucopyranoside

Mu-6S-Palm-β-Glc is a fluorogenic substrate specifically designed for palmitoyl-protein thioesterase (PPT). It is enzymatically cleaved by PPT1 to release the fluorescent 4-methylumbelliferone (MU) moiety, enabling sensitive quantification of enzyme activity. This substrate is a critical tool in the study of infantile neuronal ceroid lipofuscinosis (INCL), a lysosomal storage disorder. It is utilized for both prenatal and postnatal diagnostic assays, as well as in the evaluation of bi-functional IgG-lysosomal enzyme fusion proteins for brain-targeted drug delivery.