3 (2 hydroxyphenyl) 2 propenal

3-(2-Hydroxyphenyl)-2-propenal is a natural phenylpropanal isolated from the bark of the cassia cinnamon (Cinnamomum cassia). 3-(2-Hydroxyphenyl)-2-propenal inhibits the proliferation of various tumor cells and induces apoptosis by directly binding to STAT3 and inhibiting its phosphorylation at Tyr705 and nuclear translocation, while simultaneously regulating the expression of downstream target genes by inhibiting the Wnt/β-catenin signaling pathway. (E)-2-Hydroxycinnamaldehyde possesses antitumor activity and can be used in tumor research.