25-hydroxycholesterol

25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis

22-NBD 25-hydroxycholesterol is a sterol.

25-Hydroxycholesterol-d6 (25-OHC-d6) is the deuterium-labeled form of 25-Hydroxycholesterol. The latter is a cholesterol metabolite produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. This compound effectively and selectively inhibits IgA production in B cells, with an EC50 of approximately 65 nM.

25-Hydroxycholesterol (Standard) is a reference standard for research and analysis in studies involving 25-Hydroxycholesterol. 25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis after an acute dietary cholesterol challenge. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

25-Hydroxycholesterol-D6 (Standard) is a reference standard of 25-Hydroxycholesterol-D6 intended for quantitative analysis, quality control, and related biochemical research applications. 25-Hydroxycholesterol-d6 (25-OHC-d6) is the deuterium-labeled form of 25-Hydroxycholesterol. The latter is a cholesterol metabolite produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. This compound effectively and selectively inhibits IgA production in B cells, with an EC50 of approximately 65 nM.

ent-25-Hydroxycholesterol is the enantiomer of 25-Hydroxycholesterol.

7-Keto-25-hydroxy Cholesterol, an oxysterol and proposed metabolite of 7-keto cholesterol and 7-dehydro cholesterol, binds to and activates Smoothened (Smo) at the conserved extracellular cysteine-rich domain (CRD) in a reporter assay. Additionally, it enhances the number of EGF high affinity binding sites in normal rat kidney (NRK) cells.

SR3335 (ML 176) is a selective inverse agonist of RORα that competitively inhibits the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).

27-Hydroxycholesterol (Standard) is a reference standard for research and analysis in studies involving 27-Hydroxycholesterol. 27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.

27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.