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By Target- Endogenous Metabolite
- Prostaglandin Receptor(1)
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Results for "
15-keto pgf2alpha
" in TargetMol Product Catalog- Inhibitors & Agonists1
15-keto Prostaglandin F2α
15-keto Prostaglandin F2α, 15-keto PGF2α
T3799135850-13-6
15-keto Prostaglandin F2α is a metabolite of Prostaglandin F2α that lowers intraocular pressure in rabbits.
- $498
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8-iso-15-keto Prostaglandin F2α
T36166191919-01-4
8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-iso PGF2α is a prostaglandin-like product of non-specific lipid peroxidation. In humans and monkeys, exogenously infused 8-iso PGF2α is converted to metabolites with 2 or 4 carbon atoms removed from the top side chain by β-oxidation, with a similar pattern observed in tritiated 8-iso PGF2α-infused rabbits. Early in the infusion (within 1-2 minutes), 8-iso-15-keto PGF2α is a major component of the metabolite profile, primarily comprising unmetabolized 8-iso PGF2α. 8-iso-15-keto PGF2α is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor.
- $113
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