10-deacetylbaccatin iii

10-Deacetylbaccatin-III is an intermediate for the preparation of taxol analogs, possessing anti-cancer activity.

19-Hydroxy-10-deacetylbaccatin III (compound 13), a taxane with potential antitumor activity, exhibits low cytotoxicity towards A498 and NCI-H226 cell lines, inhibiting their growth by 16.6% and 32% respectively at a concentration of 30 μg/mL [1].

10-Deacetylbaccatin III (Standard) is a reference standard for research and analysis in studies involving 10-Deacetylbaccatin III. 10-Deacetylbaccatin-III is an intermediate for taxol analog preparations with anti-cancer activity.

7-Xylosyl-10-deacetylbaccatin III is a natural product from Taxus brevifolia.

Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).

Cabazitaxel-d9 is the deuterated form of Cabazitaxel. Cabazitaxel is a semisynthetic derivative of 10-deacetylbaccatin III, which exhibits significant antitumor activity.