(r)-tomoxetine

Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft. The effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels.

Atomoxetine-d7hydrochloride (Tomoxetine-d7hydrochloride) is the deuterium-labeled version of Atomoxetine hydrochloride. This compound acts as a selective norepinephrine reuptake inhibitor, with Ki values for norepinephrine (NE), serotonin (5-HT), and dopamine (DA) transporters measured at 5 nM, 77 nM, and 1451 nM, respectively. Additionally, Atomoxetine hydrochloride serves as an effective sodium channel blocker (VGSCs) and is utilized in research concerning attention-deficit hyperactivity disorder (ADHD).