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(e/z)-go-289

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(E/Z)-GO289
T9356694522-87-7
(E Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function. The discovery of (E Z)-GO289 provides a direct link between the circadian clock and cancer regulation and reveals unique design principles underlying kinase selectivity.
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