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product2/Casein-Kinase.html

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  • Inhibitors & Agonists
    41
    TargetMol | Activity
  • Peptide Products
    5
    TargetMol | inventory
  • Recombinant Protein
    2
    TargetMol | natural
TIE-2/VEGFR-2 kinase-IN-5
T798601014407-83-0In house
TIE-2 VEGFR-2 kinase-IN-5 (TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor) is a potent agent with anti-angiogenic activity, commonly used in biomedical research focused on angiogenesis.
  • $195
In Stock
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QTY
mTOR kinase Inhibitor 2
T93151021917-65-6In house
2H-Imidazo[4,5-b]pyrazin-2-one, 1,3-dihydro-6-[6-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-[(tetrahydro-2H-pyran-4-yl)methyl]- is a potent mTOR inhibitor with IC50 of 0.176 μM and >30 μM for mTOR and PI3Kα, respectively.
  • $89
In Stock
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TargetMol | Inhibitor Sale
Casein Kinase II Inhibitor IV
T10687863598-09-8In house
Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation.
  • $79
In Stock
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TargetMol | Inhibitor Sale
met-kinase-in-2
T87952101241-90-9In house
MET kinase-IN-2, a selective and potent MET kinase inhibitor, demonstrates oral bioavailability and exhibits an IC50 value of 7.4 nM. It also possesses antitumor activity[1].
  • Inquiry Price
8-10weeks
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Casein kinase 1δ-IN-9
T64376854355-54-7
Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.
  • $88
In Stock
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QTY
TargetMol | Inhibitor Sale
Protein kinase G inhibitor-2
T9940612829-80-8
Protein kinase G inhibitor-2 exhibits antibacterial, antiviral, and antitumor activities.
  • $30
In Stock
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QTY
TargetMol | Inhibitor Sale
Casein kinase 1δ-IN-3
T64350349438-77-3
Casein kinase 1δ-IN-3 (Compound 23a) is an inhibitor of casein kinase 1 delta (CK1δ) with a pIC50 of 6.5376 M.
  • $40
In Stock
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QTY
TargetMol | Inhibitor Sale
IRAK-4 protein kinase inhibitor 2
T9631301675-24-1
IRAK-4 protein kinase inhibitor 2 is a potent inhibitor of interleukin-1 receptor-associated kinase-4 (IC50 = 4 μM).
  • $37
In Stock
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TargetMol | Inhibitor Sale
Pim-1/2 kinase inhibitor 1
T92296320-51-0
Pim-1 2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim protein kinases. This compound is valuable in cancer research, with a notable application in studying prostate cancer [1].
  • $34
In Stock
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TargetMol | Inhibitor Sale
Aurora kinase inhibitor-2
T9040331770-21-9
Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).
  • $60
In Stock
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QTY
TargetMol | Inhibitor Sale
TIE-2/VEGFR-2 kinase-IN-4
T79859433224-29-4
TIE-2 VEGFR-2 kinase-IN-4, a benzimidazole derivative, is a potent inhibitor of the tyrosine kinase receptors TIE-2 and VEGFR-2, with IC50 values of 5.2 nM and 5.1 nM, respectively. This compound is utilized in angiogenesis research [1].
  • Inquiry Price
8-10 weeks
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Casein kinase 1δ-IN-4
T79127851168-98-4
Casein kinase 1δ-IN-4 (compound 567) is a potent inhibitor of casein kinase 1δ with potential application in Alzheimer's disease research [1].
  • Inquiry Price
8-10 weeks
Size
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Rho-Kinase-IN-2
T614972573071-18-6
Rho-Kinase-IN-2 (Compound 23) is an orally active and selective inhibitor of Rho Kinase (ROCK) with CNS penetration, exhibiting a high affinity for ROCK2 with an IC50 of 3 nM. This compound is of potential interest for further investigations in Huntington's disease research [1].
  • $916
6-8 weeks
Size
QTY
Casein Kinase inhibitor A86
T394822079069-01-3
Casein Kinase inhibitor A86 is a highly effective and orally bioavailable inhibitor of casein kinase 1α (CK1α) and also inhibits CDK7 (TFIIH) and CDK9 (P-TEFb). It induces apoptosis in leukemia cells, exhibiting substantial anti-leukemic effects.
    7-10 days
    Inquiry
    Casein kinase 1δ-IN-15
    T860062765264-27-3
    Casein kinase 1δ-IN-15, an inhibitor for casein kinase 1 (CK1δ), exhibits an IC50 of 0.045 μM [1].
    • Inquiry Price
    10-14 weeks
    Size
    QTY
    Casein kinase 1δ-IN-7
    T77708764694-25-9
    Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.
    • $39
    In Stock
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    Casein kinase 1δ-IN-5
    T791541579991-10-8
    Casein kinase 1δ-IN-5 is a potent and selective CK-1δ inhibitor (IC50 = 47 nM) that exhibits neuroprotective and anti-inflammatory effects in vitro, with potential applications in neurodegenerative disease research.
    • Inquiry Price
    8-10 weeks
    Size
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    Casein Kinase inhibitor A51
    T91752079068-74-7
    Casein Kinase inhibitor A51 is an orally active casein kinase 1α (CK1α) inhibitor with anticancer activity that induces apoptosis in leukemia cells, and may be used in the study of neck cancers, acute myeloid leukemia, breast and prostate cancers.
    • $399
    In Stock
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    IRE1α kinase-IN-2
    T388411414938-21-8
    IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM and impeding IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. It also effectively inhibits the splicing of XBP1 mRNA in wild-type cell lines.
      7-10 days
      Inquiry
      Casein kinase 1δ-IN-8
      T77709851396-73-1
      Casein kinase 1δ-IN-8 is an inhibitor of casein kinase 1δ and is used to treat neurodegenerative diseases such as Alzheimer's disease type.
      • $64
      In Stock
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      Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
      TP1269247171-44-4
      Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, consisting of amino acids 475 to 491.
      • $98
      Backorder
      Size
      QTY
      Casein kinase 1δ-IN-1
      T60295851871-94-8
      Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ) and can be utilized in the study of neurodegenerative diseases, such as Alzheimer's disease.
      • $47
      In Stock
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      Casein Kinase II Substrate
      T7647595651-74-4
      Casein Kinase II Substrate, a peptide substrate, is selectively phosphorylated by casein kinase II (CK2) [1].
      • Inquiry Price
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      Casein Kinase 2 Substrate Peptide
      T76411132176-35-3
      Casein Kinase 2 Substrate Peptide, a widely recognized CK2 substrate, is synthesized with its C-terminus conjugated to 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid (EDANS). This peptide serves as a tool for determining protein kinase CK2 activity [1].
      • Inquiry Price
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      Multi-kinase-IN-2
      T639672095628-21-8
      Multi-kinase-IN-2 is an orally active inhibitor of angiokinases. multi-kinase-IN-2 significantly inhibits the activity of angiokinases such as VEGFR-1/2/3, PDGFRα/β, FGFR-1, LYN and c-KIT kinases. -IN-2 significantly attenuates phosphorylation of AKT and ERK proteins, induces apoptosis and has anticancer effects.
      • $1,520
      6-8 weeks
      Size
      QTY
      TIE-2/VEGFR-2 kinase-IN-1
      T8817453590-24-4
      TIE-2 VEGFR-2 kinase-IN-1 is employed in the synthesis of TIE-2 and or VEGFR-2 inhibitors for studying diseases associated with inappropriate angiogenesis [1].
      • $1,350
      6-8 weeks
      Size
      QTY
      TAO Kinase inhibitor 2
      T77501850467-77-5
      TAO Kinase inhibitor 2 is a TAO kinase inhibitor with an IC50 of 50-500 nM. TAO Kinase inhibitor 2 inhibits KIAA1361 and JIK with IC50s of 50-500 nM.
      • $30
      In Stock
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      RIP2 kinase inhibitor 2
      T167531581270-11-2
      RIP2 kinase inhibitor 2 is a compound that inhibits receptor-interacting protein-2 kinase (RIP2).
      • $196
      5 days
      Size
      QTY
      Pim-1/2 kinase inhibitor 2
      T872142918764-16-4
      Compound 5b, designated as Pim-1 2 kinase inhibitor 2, acts as a competitive inhibitor of both PIM-1 and PIM-2 kinases, demonstrating IC50 values of 1.31 μM and 0.67 μM, respectively. This compound exhibits potent in-vitro anticancer activity against various cancer cell lines, including myeloid leukemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2), while showing low cytotoxicity to the normal human lung fibroblast Wi-38 cell line [1].
      • Inquiry Price
      10-14 weeks
      Size
      QTY
      TIE-2/VEGFR-2 kinase-IN-3
      T79858433224-09-0
      TIE-2 VEGFR-2 kinase-IN-3, a benzimidazole derivative, is a potent inhibitor of tyrosine kinase receptors TIE-2 and VEGFR-2, with IC50 values of 6.9 nM and 3.5 nM, respectively. This compound is useful for angiogenesis research [1].
      • Inquiry Price
      8-10 weeks
      Size
      QTY
      Casein kinase 1δ-IN-14
      T77648793722-88-0
      Casein kinase 1δ-IN-14 (WAY-637081) is a compound utilized in research to study atherosclerosis-related cardiovascular disease.
      • $39
      In Stock
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      QTY
      PI3-Kinase α Inhibitor 2 (hydrochloride)
      T355261188890-32-5
      PI3-Kinase α Inhibitor 2 (hydrochloride) is a PI3-Kinase α inhibitor.
      • $183
      35 days
      Size
      QTY
      Glutamate-5-kinase-IN-2
      T60645
      Glutamate-5-kinase-IN-2 (compound 54) is a potent glutamate-5-kinase (G5K) inhibitor with an MIC of 4.2 μM, exhibiting G5K inhibition by promoting conformational changes at the L-glutamate binding site. Glutamate-5-kinase-IN-2 has potential for anti-TB research [1].
      • $1,520
      10-14 weeks
      Size
      QTY
      Multi-target kinase inhibitor 2
      T81739
      Compound 5K (Multi-target kinase inhibitor 2) is a multi-targeted kinase inhibitor demonstrating activity against EGFR, Her2, VEGFR2, and CDK2 with IC50 values between 40 to 204 nM. It exhibits cytotoxic effects on HepG2, HeLa, MDA-MB-231, and MCF-7 cell lines, with IC50 values of 41, 57, 51, and 59 μM, respectively. Additionally, it induces cell cycle arrest and apoptosis specifically in HepG2 cells.
      • Inquiry Price
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      Casein Kinase II Receptor Peptide
      T76383198481-81-1
      Casein Kinase II Receptor Peptide, a substrate for casein kinase II, exhibits a Km value of 500 µM. It is utilized to measure the activity of casein kinase II in crude enzyme preparations [1].
      • Inquiry Price
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      Casein kinase 1δ-IN-10
      T79697332074-85-8
      Casein kinase 1δ-IN-10 is an inhibitor of casein kinase 1δ (CK1δ).
      • Inquiry Price
      8-10 weeks
      Size
      QTY
      Pim-1 kinase inhibitor 2
      T620012543624-91-3
      Pim-1 kinase inhibitor 2 (Compound 13) is a potent inhibitor of Pim-1 kinase with potential for cancer research due to its ability to induce apoptosis [1].
      • $1,520
      10-14 weeks
      Size
      QTY
      Casein kinase 1δ-IN-6
      T775001579991-01-7
      Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM, demonstrating neuroprotective and anti-inflammatory activity in both in vitro and in vivo assays. Casein kinase 1δ-IN-6 can be used to study neurodegenerative diseases.
      • $129
      In Stock
      Size
      QTY
      Casein Kinase II Inhibitor IV Hydrochloride
      T10687L2320347-54-2
      Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocyte differentiation, offering novel therapeutic approaches for treating skin hyperproliferative disorders.
      • $1,520
      1-2 weeks
      Size
      QTY
      PI3-Kinase α Inhibitor 2
      T35525371943-05-4
      Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kγ is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit. PI3Kα inhibitor 2 is a selective inhibitor of PI3Kα with IC50 values of 2, 16, 660, and 220 nM for the α, β, γ, and 2Cβ isoforms, respectively. It inhibits PKA, KDR, PKCα, and cyclin E/Cdk2 significantly less effectively (IC50 = 91, 3.4, 466, and 28 μM, respectively). PI3Kα inhibitor 2 inhibits A375 melanoma cell proliferation with an IC50 value of 580 nM.
      • $68
      35 days
      Size
      QTY
      Casein Kinase Substrates 3
      TP1509154444-97-0
      Casein Kinase Substrates 3 (CKS3) is a substrate of casein kinase (CK).
      • Inquiry Price
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