Home Tools
Log in
Cart

NOS

Nitric oxide synthases(NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2738 Dehydroandrographolide 134418-28-3 99.09%
Dehydroandrographolide
Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees.
T77499 MSU-42011 2456434-36-7 99.04%
MSU-42011
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
T10459 Banoxantrone dihydrochloride 252979-56-9 98.93%
Banoxantrone dihydrochloride
Banoxantrone dihydrochloride (AQ4N dihydrochloride) is a novel hypoxic cytotoxin that selectively kills hypoxic cells through an iNOS-dependent mechanism.
T4S0800 Demethyleneberberine 25459-91-0 98.54%
Demethyleneberberine
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
T3884 Neoandrographolide 27215-14-1 98.52%
Neoandrographolide
Neoandrographolide (Neoandrographiside) has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has a...
TN1622 Ermanin 20869-95-8 98.46%
Ermanin
Ermanin is a flavonoid isolated from Tanacetum microphyllum.Ermanin inhibits platelet aggregation and has anti-tuberculosis and anti-viral/bacterial properties.E...
TN1524 Continentalic acid 19889-23-7 98.39%
Continentalic acid
Continentalic acid from Aralia continentalis has minimum inhibitory concentrations (MICs) of approximately 8-16 µg/mL against S. aureus, including the Methicilli...
T125120 Cyclo(L-Pro-L-Val) 2854-40-2 98.18%
Cyclo(L-Pro-L-Val)
Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory act...
T6S1256 Ruscogenin 472-11-7 98.12%
Ruscogenin
1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin ...
T21967 MEG hemisulfate 3979-00-8 98.09%
MEG hemisulfate
MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values ...
TN1222 26-Deoxyactein 264624-38-6 98.06%
26-Deoxyactein
23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity...
TN1650 Friedelin 559-74-0 98%
Friedelin
Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.
T7543 S-(2-aminoethyl) Isothiourea (dihydrobromide) 56-10-0 98%
S-(2-aminoethyl) Isothiourea (dihydrobromide)
S-(2-aminoethyl) Isothiourea (dihydrobromide) is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0...
T5688 Micheliolide 68370-47-8 98%
Micheliolide
Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
T0947 Dexamethasone acetate 1177-87-3 98%
Dexamethasone acetate
Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addi...
T7191 Diphenyleneiodonium chloride 4673-26-1 98%
Diphenyleneiodonium chloride
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum...
TN2440 Sinapyl alcohol 537-33-7 97.28%
Sinapyl alcohol
Technical grade is a natural from Magnolia sieboldii
TN1373 α-Humulene 6753-98-6 97.18%
α-Humulene
α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory e...
T22761 EIT hydrobromide 1071-37-0 96.85%
EIT hydrobromide
EIT hydrobromide (S-Ethylisothiourea hydrobromide) is an iNOS inhibitor.
T11518L GW274150 210354-22-6 96.43%
GW274150
GW274150 is an orally active, selective and potent dual inhibitor of NADPH-dependent human nitric oxide synthase (iNOS) (Kd=40 nM) and rat inducible nitric oxide...
Dehydroandrographolide
T2738
Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees.
MSU-42011
T77499
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
Banoxantrone dihydrochloride
T10459
Banoxantrone dihydrochloride (AQ4N dihydrochloride) is a novel hypoxic cytotoxin that selectively kills hypoxic cells through an iNOS-dependent mechanism.
Demethyleneberberine
T4S0800
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
Neoandrographolide
T3884
Neoandrographolide (Neoandrographiside) has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has a...
Ermanin
TN1622
Ermanin is a flavonoid isolated from Tanacetum microphyllum.Ermanin inhibits platelet aggregation and has anti-tuberculosis and anti-viral/bacterial properties.E...
Continentalic acid
TN1524
Continentalic acid from Aralia continentalis has minimum inhibitory concentrations (MICs) of approximately 8-16 µg/mL against S. aureus, including the Methicilli...
Cyclo(L-Pro-L-Val)
T125120
Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory act...
Ruscogenin
T6S1256
1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin ...
MEG hemisulfate
T21967
MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values ...
26-Deoxyactein
TN1222
23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity...
Friedelin
TN1650
Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.
S-(2-aminoethyl) Isothiourea (dihydrobromide)
T7543
S-(2-aminoethyl) Isothiourea (dihydrobromide) is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0...
Micheliolide
T5688
Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
Dexamethasone acetate
T0947
Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addi...
Diphenyleneiodonium chloride
T7191
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum...
Sinapyl alcohol
TN2440
Technical grade is a natural from Magnolia sieboldii
α-Humulene
TN1373
α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory e...
EIT hydrobromide
T22761
EIT hydrobromide (S-Ethylisothiourea hydrobromide) is an iNOS inhibitor.
GW274150
T11518L
GW274150 is an orally active, selective and potent dual inhibitor of NADPH-dependent human nitric oxide synthase (iNOS) (Kd=40 nM) and rat inducible nitric oxide...
1 2 3 4 5 6
TargetMol