T79741 |
CARM1 degrader-1
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98%
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PROTAC CARM1 degrader-1 (compound 3b) serves as a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1). This co...
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T79742 |
CARM1 degrader-2
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98%
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PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associated argininemethyltransfer...
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T79776 |
ZZM-1220
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98%
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ZZM-1220, a covalent inhibitor of histone lysine methyltransferase G9a/GLP, exhibits IC50 values of 458 nM for G9a and 924 nM for GLP. It effectively inhibits H3...
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T79780 |
IHMT-EZH2-426
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98%
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IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5 nM...
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T79849 |
Igermetostat
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2409538-60-7
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98%
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Igermetostat, an EZH2 inhibitor, is utilized both in vivo and in vitro for cancer research [1].
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T79873 |
TNG-462
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2760483-96-1
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98%
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TNG-462 (Compound 1143) is a PRMT5 inhibitor with oral activity, being investigated for use in MTAP-deficient and/or MTA-accumulating cancers [1].
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T81175 |
SETD7-IN-1
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98%
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SETD7-IN-1 (compound 7), a PFI-2 analogue, acts as both a substrate and inhibitor of histone lysine methyltransferase SETD7, exhibiting an inhibitory concentrati...
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T13279 |
Valemetostat tosylate
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1809336-93-3
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98%
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Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.
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T12886 |
SGC-iMLLT
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2255338-25-9
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98%
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SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target enga...
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T12428 |
PF-06726304 acetate
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2080306-28-9
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98%
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PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
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T12939 |
SMYD2-IN-1
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2023788-96-5
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98%
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SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
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T74542 |
YM458
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2770108-93-3
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98%
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YM458, a potent dual inhibitor of EZH2 and BRD4, exhibits IC50 values of 490 nM and 34 nM, respectively. This compound effectively hinders cell proliferation and...
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T11185 |
EML741
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2328074-38-8
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98%
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EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barri...
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T36798L |
SW2_110A acetate
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98%
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SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD). SW2_110A acetate ...
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T11500 |
GSK3368715
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1629013-22-4
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98%
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GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
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T11082 |
Dot1L-IN-2
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1940206-71-2
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98%
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Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively....
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T15240 |
Tazemetostat trihydrochloride
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1403255-00-4
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98%
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Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
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T11081 |
Dot1L-IN-1
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2088518-50-5
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98%
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The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
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T12541 |
PRMT5-IN-1
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2366149-83-7
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98%
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PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
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T68378 |
PRMT4-IN-1
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912970-79-7
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98%
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PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].
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