DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

Cat. No.	Product name	CAS No.	Purity
TN4227	Horminone	21887-01-4	98%
TN4227	Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi,...
T2627	Nolatrexed dihydrochloride	152946-68-4	98%
T2627	Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrex...
TN3691	Communic acid	2761-77-5	98%
TN3691	Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
TN4913	Riddelline	23246-96-0	98%
TN4913	Riddelline is a potent genotoxic agent in vitro and induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver.
T7429	Datelliptium chloride	105118-14-7	98%
T7429	Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride shows anti-tumor activities.
TN3587	Capillarisin	56365-38-9	98%
TN3587	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN4938	Samidin	477-33-8	98%
TN4938	Samidin has anti-inflammatory properties through suppression of NF-ÎºB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
TN4394	Kobophenol A	124027-58-3	98%
TN4394	Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
T37101	1-Hydroxyanthraquinone	129-43-1	98%
T37101	1-Hydroxyanthraquinone is an anthraquinone that has been found inMorinda officinalisand has genotoxic and carcinogenic activities.1,21-Hydroxyanthraquinone (5 an...
T33272	Mefenidil	58261-91-9	98%
T33272	Mefenidil, a selective cerebral vasodilator, was shown to increase CBF in healthy brains without stimulating O2 uptake in a dog anesthesia model.
TN1660	Ganoderic acid C1	95311-97-0	98%
TN1660	Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
T23384	SR 11302	160162-42-5	98%
T23384	SR 11302 is an inhibitor of activator protein-1 (AP-1).
T6116L	Bleomycin hydrochloride	67763-87-5	98%
T6116L	Bleomycin hydrochloride is a potent antitumor antibiotic that functions as a DNA synthesis inhibitor and DNA damaging agent.
TNU0839	1,4-Dideoxy-1,4-epithio-D-ribitol	190315-43-6	98%
TNU0839	1,4-Dideoxy-1,4-epithio-D-ribitol is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and possesses a broad spectrum of ant...
T14522	Beaucage reagent	66304-01-6	98%
T14522	Beaucage reagent, which is found to be effective in causing DNA cleavage.
T28762	Setrobuvir	1071517-39-9	98%
T28762	Setrobuvir is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s betw...
T60420	Anticancer agent 73	124811-87-6	98%
T60420	Anticancer agent 73 is an anticancer agent which potently targets transactivation response(TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interac...
T38427	DUTP trisodium	102814-08-4	98%
T38427	dUTP trisodium is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR.
T20038	2-Fluoroadenine	700-49-2	98%
T20038	2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for anticancer studies.
T5530	Mithramycin A	18378-89-7	98%
T5530	Mithramycin A, a DNA-binding antitumor antibiotic, is a selective specificity protein 1 (Sp1) inhibitor, which inhibits the growth of various cancers by decreas...