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By Target- Tie-2
- VEGFR(1)
- c-Met/HGFR(1)
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Results for "
xl-880
" in TargetMol Product Catalog- Inhibitors & Agonists1
Foretinib
GSK089, EXEL-2880, GSK1363089, XL880
T3113849217-64-7
Foretinib (GSK1363089) is a broad-spectrum tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR.
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T711871226999-07-0
Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers.
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