vsig 3

Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and or the acrosome reaction. IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. In clinical, the IGSF11 has been reported to overexpressed in colorectal cancers and hepatocellular carcinomas, as well as intestinal-type gastric cancers, compared to their corresponding non-cancerous tissues. The IGSF11 has also been found expressed abundantly in the testis and ovary and the IGSF11 can be used as a candidate of cancer-testis antigen.

Expression system: HEK293 Cells
Length: 23-245, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 23-240, Partial
Activity: Not Tested

T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: BLI、ELISA

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

TIGIT Protein, Human, Recombinant (aa 22-141, His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 14.51 kDa and the accession number is NP_776160.2.