vismodegib

Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).

Vismodegib-D4 ismodegib-D4 is a deuterated compound of Vismodegib. Vismodegib (T2590) has a CAS number of 879085-55-9. Vismodegib (T2590) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).

Vismodegib-D7 ismodegib-D7 is a deuterated compound of Vismodegib. Vismodegib (T2590) has a CAS number of 879085-55-9. Vismodegib (T2590) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).

Vismodegib-[13C7,D3] (Standard) is a reference standard of Vismodegib-[13C7,D3] intended for quantitative analysis, quality control, and related biochemical research applications.

NL-103 is a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. NL-103 comprises structural elements of Hh pathway inhibitor vismodegib, and histone deacetylase (HDAC) inhibitor vorinostat. NL-103 simultaneously and significantly inhibited both HDACs and Hh pathway. Importantly, NL-103 effectively overcame vismodegib resistance induced by Smoothened point mutations. Moreover, NL-103 significantly downregulated the expression of Gli2 which plays an important role in Hh pathway. NL-103 may be a promising compound for clinical development as a more effective Hh pathway inhibitor.