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Results for "
topovale
" in TargetMol Product Catalog- Inhibitors & Agonists1
Topovale
ARC111, ARC 111, ARC-111, Topoval
T9088500214-53-9
Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388 CPT45 cells as compared with P388 cells.
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